Reactive species produced in the cell during normal cellular metabolism can chemically
react with cellular biomolecules such as nucleic acids, proteins, and lipids, thereby causing …

Alzheimer's disease (AD) is the most common progressive human neurodegenerative
disorder affecting elderly population worldwide. Hence, prevention of AD has been a priority …

The amyloid-β (Aβ) peptide is associated with the development of Alzheimer's disease and
is known to form highly neurotoxic prefibrillar oligomeric aggregates, which are difficult to …

Zebrafish (Danio rerio) have become a powerful tool in neuroscience research due to their
genetic tractability, molecular/physiological conservation, small body size, ease of …

John A. Hardy and Gerald A. Higgins and tau phosphorylation can be controlled by
intracellular calcium (22). Thus, APP may induce neurofibrillary tangle formation as a …

Peptides or proteins convert under some conditions from their soluble forms into highly
ordered fibrillar aggregates. Such transitions can give rise to pathological conditions ranging …

Although extensive data support a central pathogenic role for amyloid β protein (Aβ) in
Alzheimer's disease, the amyloid hypothesis remains controversial, in part because a …

Aβ1–42 is a self-associating peptide whose neurotoxic derivatives are thought to play a role
in Alzheimer's pathogenesis. Neurotoxicity of amyloid β protein (Aβ) has been attributed to …

The'toxic Aβ oligomer'hypothesis has attracted considerable attention among Alzheimer's
disease researchers as a way of resolving the lack of correlation between deposited amyloid …

Alzheimer's disease (AD) involves amyloid β (Aβ) accumulation, oxidative damage, and
inflammation, and risk is reduced with increased antioxidant and anti-inflammatory …