Ruxolitinib for the treatment of acute and chronic graft-versus-host disease in children: a systematic review and individual patient data meta-analysis

F Baccelli, F Gottardi, E Muratore, D Leardini… - Bone Marrow …, 2024 - nature.com
Steroid-refractory graft-versus-host disease (SR-GvHD) represents a major complication of
pediatric allogenic hematopoietic stem cell transplantation. Ruxolitinib, a selective JAK 1–2 …

An open‐label study of belumosudil, a selective ROCK2 inhibitor, as second or subsequent line of therapy for steroid‐dependent/steroid‐resistant chronic GVHD

Y Inamoto, K Kato, T Kawakita, Y Onishi… - American Journal of …, 2024 - Wiley Online Library
Belumosudil mesylate is a selective Rho‐associated coiled‐coil kinase 2 inhibitor with
immunomodulatory and antifibrosis effects. This multicenter, open‐label, single‐arm study …

[HTML][HTML] A Biobehavioral Perspective on Caring for Allogeneic Hematopoietic Stem Cell Transplant Survivors with Graft-Versus-Host Disease

S Lahijani, M Rueda-Lara, N McAndrew… - … and cellular therapy, 2024 - Elsevier
Among the potential complications of allogeneic hematopoietic stem cell transplantation
(HSCT), graft-versus-host disease (GVHD) is common and associated with significant …

Development and psychometric testing of a pediatric chronic graft-versus-host disease symptom scale: protocol for a two-phase, mixed methods study

SA Mitchell, R Hunter, A Fry, SZ Pavletic… - Frontiers in …, 2024 - frontiersin.org
Background Chronic graft-versus-host disease (cGVHD) is a debilitating late complication of
hematopoietic stem cell transplantation. It is often accompanied by extensive symptom …

Early intervention with oral mucosal barrier Protective agents in chronic oral graft-versus-host disease: a retrospective cohort study

J Cao, L Ye, X Li, Q Song, Y Chai - BMC Oral Health, 2024 - Springer
Background Preventing the progression of chronic oral graft-versus-host disease (cGVHD) is
essential for maintaining oral health, improving quality of life, minimizing functional …

Treatment of steroid-refractory graft versus host disease in children

F Gottardi, D Leardini, E Muratore, F Baccelli… - Frontiers in …, 2023 - frontiersin.org
Systemic steroids are still the first-line approach in acute graft-versus-host disease (aGvHD),
and the backbone of chronic GvHD management. Refractoriness to steroid represent a …

Improvement of survival after hematopoietic stem cell transplantation and trends at a pediatric transplantation center; a three‐decade journey

G Sezgin, YS Öner, G İnan, İ Ünal… - Pediatric …, 2024 - Wiley Online Library
Background Advances in stem cell transplantation have resulted in improved outcomes.
Methods This is a retrospective study aimed to analyze changes in patient profile …

Vitamin A keeps the GVHD away?

Z DeFilipp - Blood, 2024 - ashpublications.org
In this issue of Blood, Khandelwal et al report on the results of a randomized, placebo-
controlled phase 2 trial, in which a single dose of oral vitamin A given prior to conditioning …

What Is Next in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

AC Talleur, CH Pui, SE Karol - Lymphatics, 2023 - mdpi.com
Cure rates now exceed 90% in many contemporary trials for children with B-cell acute
lymphoblastic leukemia (B-ALL). However, treatment remains suboptimal, and therapy is …

[HTML][HTML] Социально-экономическое бремя хронической реакции «трансплантат против хозяина» после аллогенной пересадки костного мозга

АС Колбин, ЮМ Гомон, МА Проскурин… - Качественная …, 2024 - cyberleninka.ru
Цель исследования. Оценка социально-экономического бремени хронической реакции
«трансплантат против хозяина»(хрРТПХ) в Российской Федерации. Материалы и …