Environmental exposures have long been known to impact public health and safety. For
example, exposures to airborne particulates, heavy metals in water, or certain industrial …

Lidocaine has not been associated with cancer in humans despite 8 decades of therapeutic
use. Its metabolite, 2, 6-xylidine, is a rat carcinogen, believed to induce genotoxicity via N …

Abstract Di-(2-ethylhexyl) phthalate (DEHP), the common plasticizer used in the production
of polyvinyl chloride, can be converted to the more potent metabolite mono-ethylhexyl …

The single cell gel electrophoresis assay, also known as the comet assay, is a versatile
method for measuring many classes of DNA damage, including base damage, abasic sites …

Primary aromatic amines (pAAs) are attractive building blocks in medicinal chemistry
programmes yet their potential for mutagenic activity causes real concern owing to the risk of …

Methyl-6-ethylaniline (MEA) is the main microbial degradation intermediate of the
chloroacetanilide herbicides acetochlor and metolachlor. Sphingobium sp. strain MEA3-1 …

Background Conflicting results between bacterial mutagenicity tests (the Ames test) and
mammalian carcinogenicity tests might be due to species differences in metabolism …

3, 4-Dimethylaniline (3, 4-DMA) is present in cigarette smoke and widely used as an
intermediate in dyes, drugs, and pesticides. Nucleotide excision repair-deficient Chinese …

Exposure to alkylanilines found in tobacco smoke and indoor air is associated with risk of
bladder cancer. Genetic factors significantly influence the metabolism of arylamine …

Primary aromatic and heteroaromatic amines are notoriously known as potential mutagens
and carcinogens. The major event of the mechanism of their mutagenicity is N-hydroxylation …