An insight of microRNAs performance in carcinogenesis and tumorigenesis; an overview of cancer therapy

K Babaei, S Shams, A Keymoradzadeh, S Vahidi… - Life sciences, 2020 - Elsevier
Importance of dysregulation and expression of microRNAs (miRNAs) has been confiemed in
many disorders comprising cancer. In this way, different approaches to induce …

Clinical and prognostic significances of cancer stem cell markers in gastric cancer patients: a systematic review and meta-analysis

M Razmi, R Ghods, S Vafaei, M Sahlolbei… - Cancer Cell …, 2021 - Springer
Background Gastric cancer (GC) is considered one of the most lethal malignancies
worldwide, which is accompanied by a poor prognosis. Although reports regarding the …

Current understanding of epigenetics mechanism as a novel target in reducing cancer stem cells resistance

S Keyvani-Ghamsari, K Khorsandi, A Rasul… - Clinical …, 2021 - Springer
At present, after extensive studies in the field of cancer, cancer stem cells (CSCs) have been
proposed as a major factor in tumor initiation, progression, metastasis, and recurrence …

Regulation of formation, stemness and therapeutic resistance of cancer stem cells

N Jing, WQ Gao, YX Fang - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Over the past 20 years cancer stem cells (CSCs) have been proposed as key players in the
tumorigenesis and progression, which are closely related to the initiation, metastasis and …

Gastric cancer stem cells: current insights into the immune microenvironment and therapeutic targets

L Fu, L Bu, T Yasuda, M Koiwa, T Akiyama, T Uchihara… - Biomedicines, 2020 - mdpi.com
Gastric cancer (GC) is a leading cause of cancer-related death worldwide. Cancer stem cells
(CSCs) are known to be involved in chemotherapy resistance and the development of …

[HTML][HTML] Cancer stem cells: a major culprit of intra-tumor heterogeneity

F Naz, M Shi, S Sajid, Z Yang, C Yu - American journal of cancer …, 2021 - ncbi.nlm.nih.gov
Cancer is recognized as a preeminent factor of the world's mortality. Although various
modalities have been designed to cure this life-threatening ailment, a significant impediment …

MicroRNAs as regulators of immune checkpoints in cancer immunotherapy: targeting PD-1/PD-L1 and CTLA-4 pathways

A Zabeti Touchaei, S Vahidi - Cancer Cell International, 2024 - Springer
Immunotherapy has revolutionized cancer treatment by harnessing the power of the immune
system to eliminate tumors. Immune checkpoint inhibitors (ICIs) block negative regulatory …

Celastrus orbiculatus extract suppresses gastric cancer stem cells through the TGF-β/Smad signaling pathway

T Ni, Z Chu, L Tao, Y Zhao, M Lv, M Zhu, Y Luo… - Journal of Natural …, 2024 - Springer
Cancer stem cells (CSCs) are the primary source of tumor recurrence and chemoresistance,
which complicates tumor treatment and has a significant impact on poor patient prognosis …

A brain-penetrating Hsp90 inhibitor NXD30001 inhibits glioblastoma as a monotherapy or in combination with radiation

H Chen, Y Gong, Y Ma, RC Thompson… - Frontiers in …, 2020 - frontiersin.org
Glioblastoma multiforme (GBM) is a highly heterogeneous disease, which is initiated and
sustained by various molecular alterations in an array of signal transduction pathways. Heat …

METTL14 attenuates cancer stemness by suppressing ATF5/WDR74/β‐catenin axis in gastric cancer

P Zhang, H Xiang, Q Peng, L Ma, C Weng… - Cancer …, 2025 - Wiley Online Library
Stemness is a key factor contributing to treatment failure in gastric cancer (GC).
Methyltransferase‐like 14 (METTL14) has been linked to various cancers, though its specific …