The MET oncogene encodes an unconventional receptor tyrosine kinase with pleiotropic
functions: it initiates and sustains neoplastic transformation when genetically altered …

Tetraspanins are a family of proteins with four transmembrane domains that play a role in
many aspects of cell biology and physiology; they are also used by several pathogens for …

Tetraspanins are molecular scaffolds that distribute proteins into highly organized
microdomains consisting of adhesion, signaling, and adaptor proteins. Many reports have …

An abundance of evidence shows supporting roles for tetraspanin proteins in human cancer.
Many studies show that the expression of tetraspanins correlates with tumour stage, tumour …

Integrins play an important role in cell adhesion by linking the cytoskeleton of cells to
components in the extracellular matrix. In this capacity, integrins cooperate with different cell …

Plexin transmembrane receptors and their semaphorin ligands, as well as their co-receptors
(Neuropilin, Integrin, VEGFR2, ErbB2, and Met kinase) are emerging as key regulatory …

Originally identified as a molecular organizer of interacting proteins into tetraspanin-
enriched microdomains, the tetraspanin CD151 has now been shown to be involved in …

Post‐translational protein modifications, such as tyrosine phosphorylation, regulate protein–
protein interactions (PPI s) critical for signal processing and cellular phenotypes. We …

The c-Met receptor, also known as the HGF receptor, is one of the most studied tyrosine
kinase receptors, yet its biological functions and activation mechanisms are still not fully …

Background: CD151 is highly expressed in breast cancer cells and has been shown to
accelerate breast cancer by enhancing cell growth and motility, but its regulation is poorly …