The role of circadian clock genes in colorectal carcinoma: novel insights into regulatory mechanism and implications in clinical therapy
H Zhu, J Chen, Z Wen, J Li, Q Yu, W Liao, X Luo - Life Sciences, 2023 - Elsevier
Colorectal cancer (CRC) is a lethal malignancy with limited treatment strategies.
Accumulating evidence indicates that CRC tumorigenesis, progression and metastasis are …
Accumulating evidence indicates that CRC tumorigenesis, progression and metastasis are …
Crosstalk between DNA methylation and gene mutations in colorectal cancer
M Dobre, A Salvi, IA Pelisenco, F Vasilescu… - Frontiers in …, 2021 - frontiersin.org
Colorectal cancer (CRC) is often characterized by mutations and aberrant DNA methylation
within the promoters of tumor suppressor genes and proto-oncogenes. The most frequent …
within the promoters of tumor suppressor genes and proto-oncogenes. The most frequent …
Dickkopf-related protein 2 is epigenetically inactivated and suppresses colorectal cancer growth and tumor metastasis by antagonizing Wnt/β-catenin signaling
C Wang, Y Yue, B Shao, Z Qiu, J Mu, J Tang… - Cellular Physiology and …, 2017 - karger.com
Abstract Background/Aims: Aberrant activation of the Wnt/β-catenin signaling pathway plays
a key role in the pathogenesis of multiple tumors including digestive cancers. Recent studies …
a key role in the pathogenesis of multiple tumors including digestive cancers. Recent studies …
CircEHMT1 inhibits metastatic potential of breast cancer cells by modulating miR-1233-3p/KLF4/MMP2 axis
M Lu, Y Wu, B Zeng, J Sun, Y Li, J Luo, L Wang… - Biochemical and …, 2020 - Elsevier
CircRNA is a kind of covalent head-to-tail looped RNA and plays an important role in tumor
development. However, the identification of new potential targetable circRNAs to inhibit …
development. However, the identification of new potential targetable circRNAs to inhibit …
Serum cell-free DNA methylation of OPCML and HOXD9 as a biomarker that may aid in differential diagnosis between cholangiocarcinoma and other biliary …
W Wasenang, P Chaiyarit, S Proungvitaya… - Clinical …, 2019 - Springer
Background Cholangiocarcinoma (CCA) is a fatal cancer of the bile duct epithelial cell
lining. The misdiagnosis of CCA and other biliary diseases may occur due to the similarity of …
lining. The misdiagnosis of CCA and other biliary diseases may occur due to the similarity of …
mir-122 inhibits metastasis and epithelial–mesenchymal transition of non-small-cell lung cancer cells
H Qin, J Sha, C Jiang, X Gao, L Qu, H Yan… - OncoTargets and …, 2015 - Taylor & Francis
miR-122 may function as a novel tumor suppressor. Expression of miR-122 could suppress
the proliferation of multi-kinds of human cancer cell lines. In this work, expression of miR …
the proliferation of multi-kinds of human cancer cell lines. In this work, expression of miR …
[HTML][HTML] Protocadherin 17 functions as a tumor suppressor suppressing Wnt/β-catenin signaling and cell metastasis and is frequently methylated in breast cancer
Protocadherins play important roles in the regulation of cell adhesion and signaling
transduction. Aberrant expression of protocadherins has been shown to be associated with …
transduction. Aberrant expression of protocadherins has been shown to be associated with …
Identification of a robust methylation classifier for cutaneous melanoma diagnosis
Early diagnosis improves melanoma survival, yet the histopathological diagnosis of
cutaneous primary melanoma can be challenging, even for expert dermatopathologists …
cutaneous primary melanoma can be challenging, even for expert dermatopathologists …
Effect of luteolin on the methylation status of the OPCML gene and cell growth in breast cancer cells
X Dong, J Zhang, F Yang, J Wu… - Experimental and …, 2018 - spandidos-publications.com
The present study aimed to investigate the effect of luteolin on the methylation of opioid
binding protein/cell adhesion molecule (OPCML) in breast cancer cells, as well as its …
binding protein/cell adhesion molecule (OPCML) in breast cancer cells, as well as its …
Interaction between prenatal pesticide exposure and a common polymorphism in the PON1 gene on DNA methylation in genes associated with cardio-metabolic …
K Declerck, S Remy, C Wohlfahrt-Veje, KM Main… - Clinical …, 2017 - Springer
Background Prenatal environmental conditions may influence disease risk in later life. We
previously found a gene-environment interaction between the paraoxonase 1 (PON1) …
previously found a gene-environment interaction between the paraoxonase 1 (PON1) …