The posttranslational modification with ubiquitin, a process referred to as ubiquitylation,
controls almost every process in cells. Ubiquitin can be attached to substrate proteins as a …

DNA double-strand breaks (DSBs) are highly cytotoxic DNA lesions. The swift recognition
and faithful repair of such damage is crucial for the maintenance of genomic stability, as well …

INTRODUCTION Histone modification activity of the polycomb repressive complexes 1 and
2 (PRC1 and PRC2) is critical for the establishment and maintenance of gene expression …

Ubiquitin acts as a versatile cellular signal that controls a wide range of biological processes
including protein degradation, DNA repair, endocytosis, autophagy, transcription, immunity …

Protein ubiquitination and protein phosphorylation are two fundamental regulatory post-
translational modifications controlling intracellular signalling events. However, the ubiquitin …

Ubiquitin-binding domains (UBDs) are modular elements that bind non-covalently to the
protein modifier ubiquitin. Recent atomic-level resolution structures of ubiquitin–UBD …

Genome integrity is constantly monitored by sophisticated cellular networks, collectively
termed the DNA damage response (DDR). A common feature of DDR proteins is their …

Protein ubiquitination at sites of DNA double-strand breaks (DSBs) by RNF168 recruits
BRCA1 and 53BP1,, which are mediators of the homologous recombination and non …

Inactivation of the TNFAIP3 gene, encoding the A20 protein, is associated with critical
inflammatory diseases including multiple sclerosis, rheumatoid arthritis and Crohn's …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …