Rho GTPases regulate cytoskeletal and cell adhesion dynamics and thereby coordinate a
wide range of cellular processes, including cell migration, cell polarity and cell cycle …

Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in
regulating multiple signal transduction pathways that influence a diverse range of cellular …

Rho GTPases are well known for their roles in regulating cell migration, and also contribute
to a variety of other cellular responses. They are subdivided into 2 groups: typical and …

G protein–coupled receptor (GPCR) signaling is precisely controlled to avoid
overstimulation that results in detrimental consequences. Gβγ signaling is negatively …

Cullin proteins are molecular scaffolds that have crucial roles in the post-translational
modification of cellular proteins involving ubiquitin. The mammalian cullin protein family …

Neddylation, a post-translational modification that conjugates an ubiquitin-like protein
NEDD8 to substrate proteins, is an important biochemical process that regulates protein …

Neddylation, a post-translational modification that adds an ubiquitin-like protein NEDD8 to
substrate proteins, modulates many important biological processes, including …

Packaging of proteins from the endoplasmic reticulum into COPII vesicles is essential for
secretion. In cells, most COPII vesicles are approximately 60–80 nm in diameter, yet some …

Copy-number variants of chromosome 16 region 16p11. 2 are linked to neuropsychiatric
disorders,,,,, and are among the most prevalent in autism spectrum disorders,,. Of many …

Neddylation, the covalent attachment of ubiquitin-like protein Nedd8, of the Cullin-RING E3
ligase family regulates their ubiquitylation activity. However, regulation of HECT ligases by …