Extrachromosomal DNA (ecDNA) amplification is an important driver alteration in cancer. It
has been observed in most cancer types and is associated with worse patient outcome. The …

Extrachromosomal circular DNA (eccDNA) is a double-stranded DNA molecule found in
various organisms, including humans. In the past few decades, the research on eccDNA has …

Extrachromosomal circular DNA (ecDNA) has gained renewed interest since its discovery
more than half a century ago, emerging as critical driver of tumor evolution. ecDNA is highly …

Epigenetic modifications of histones are associated with development and pathogenesis of
disease. Existing approaches cannot provide insights into long-range interactions and …

Extrachromosomal DNA (ecDNA) is a special class of circular DNA in eukaryotes, which is
independent of conventional chromosomes. These circular molecules play important roles in …

Extrachromosomal DNA (ecDNA), derived from chromosomes, is a cancer-specific circular
DNA molecule. EcDNA drives tumor initiation and progression, which is associated with …

Extrachromosomal circular DNA (eccDNA) is a class of circular DNA molecules that
originate from genomic DNA but are separate from chromosomes. They are common in …

Background High oncogene expression in cancer cells is a major cause of rapid tumor
progression and drug resistance. Recent cancer genome research has shown that …

Extrachromosomal DNA (ecDNA) is a form of circular DNA mostly found in tumor cells.
Unlike the typical chromosomal DNA, ecDNA is circular, self-replicating, and carries …

Extrachromosomal circular DNA (eccDNA), a pervasive yet enigmatic component of the
eukaryotic genome, exists autonomously from its chromosomal counterparts. Ubiquitous in …