CAR-T cell therapy for hematological malignancies: Limitations and optimization strategies

J Huang, X Huang, J Huang - Frontiers in immunology, 2022 - frontiersin.org
In the past decade, the emergence of chimeric antigen receptor (CAR) T-cell therapy has led
to a cellular immunotherapy revolution against various cancers. Although CAR-T cell …

[HTML][HTML] Current progress in chimeric antigen receptor-modified T cells for the treatment of metastatic breast cancer

L Yin, G Chen, Z Xiang, Y Liu, X Li, J Bi… - Biomedicine & …, 2023 - Elsevier
Breast cancer is the leading cancer in women. Around 20–30% breast cancer patients
undergo invasion or metastasis after radical surgical resection and eventually die. Number …

[HTML][HTML] Pathogen-specific T cells: targeting old enemies and new invaders in transplantation and beyond

A Papadopoulou, M Alvanou, G Karavalakis… - …, 2023 - journals.lww.com
Adoptive immunotherapy with virus-specific cytotoxic T cells (VSTs) has evolved over the
last three decades as a strategy to rapidly restore virus-specific immunity to prevent or treat …

Pre-clinical data supporting immunotherapy for HIV using CMV-HIV-specific CAR T cells with CMV vaccine

M Guan, L Lim, L Holguin, T Han, V Vyas… - … Therapy-Methods & …, 2022 - cell.com
T cells engineered to express HIV-specific chimeric antigen receptors (CARs) represent a
promising strategy to clear HIV-infected cells, but to date have not achieved clinical benefits …

Alloreactive-free CAR-VST therapy: a step forward in long-term tumor control in viral context

V Wang, B Savoldo, JA Guimaraes, G Dotti… - Frontiers in …, 2025 - frontiersin.org
CAR-T cell therapy has revolutionized immunotherapy but its allogeneic application, using
various strategies, faces significant challenges including graft-versus-host disease and graft …

[HTML][HTML] A comprehensive review of quantum bioreactor cell manufacture: Research and clinical applications

CH Hulme, C Mennan, HS McCarthy, R Davies, T Lan… - Cytotherapy, 2023 - Elsevier
The Quantum cell expansion system manufactured by Terumo-BCT is perhaps the most
widely reported Good Manufacturing Practice–compliant bioreactor used for the expansion …

Adoptive Immune Effector Cell Therapies in Cancer and Solid Organ Transplantation: A Review

B Schreiber, S Tripathi, S Nikiforow… - Seminars in …, 2024 - Elsevier
Cancer is one of the most devastating complications of kidney transplantation and
constitutes one of the leading causes of morbidity and mortality among solid organ …

Leveraging oncovirus-derived antigen against the viral malignancies in adoptive cell therapies

W Zhang, M Zeng, Y Li, L Yu - Biomarker Research, 2024 - Springer
Adoptive cell therapies (ACTs) have revolutionized cancer immunotherapy, prompting
exploration into their application against oncoviruses. Oncoviruses such as human …

Development of a highly cytotoxic, clinical-grade virus-specific T cell product for adoptive T cell therapy

FA Rocha, CRF Silveira, AF Dos Santos… - Cellular …, 2024 - Elsevier
At present, recipients of allogeneic hematopoietic stem-cells are still suffering from recurrent
infections after transplantation. Infusion of virus-specific T cells (VST) post-transplant …

Genetic Modification of T Cells for the Immunotherapy of Cancer

S Quinn, N Lenart, V Dronzek, GM Scurti, NM Hossain… - Vaccines, 2022 - mdpi.com
Immunotherapy is a beneficial treatment approach for multiple cancers, however, current
therapies are effective only in a small subset of patients. Adoptive cell transfer (ACT) is a …