Adhesive interactions between cells and collagen required for contraction are mediated by
a2/31 integrins (Schiro et al., 1991; Klein et al., 1991). Tensile force was found to depend on …

Skin, the largest organ in the body, protects against toxins and microorganisms in the
environment and serves to prevent dehydration of all non-aquatic animals. Immune …

To investigate how cells sense stiffness in settings structurally similar to native extracellular
matrices, we designed a synthetic fibrous material with tunable mechanics and user-defined …

We search in this paper for context-specific modes of three-dimensional (3D) cell migration
using imaging for phosphatidylinositol (3, 4, 5)-trisphosphate (PIP3) and active Rac1 and …

This chapter looks at variables such as fibril diameter, orientation, tissue distribution, relative
concentrations and packing of fibrils into larger volumes, and search for patterns which …

A major goal of tissue engineering is to synthesize or regenerate tissues and organs. Today,
this is done by providing a synthetic porous scaffold, or matrix, which mimics the body's own …

Conclusions The development of cultured epidermal grafts in conjunction with collagen
matrix to treat patients with life threatening major burns is a technology with potential to …

Collagen type I is a widely used natural biomaterial that has found utility in a variety of
biological and medical applications. Its well-characterized structure and role as an …

Fibroblast accumulation in a cutaneous wound requires phenotypic modulation of
fibroblasts. In response to injury, resident fibroblasts in the surrounding tissue proliferate for …

The human response to injury involves the coordinated interplay of a variety of physiologic
processes that result in a healed wound. In a highly reproducible manner, hemostasis is …