Identical disease‐causing mutations can lead to different symptoms in different people. The
reason for this has been a puzzling problem for geneticists. Differential penetrance and …

In the study of longevity, increasing importance is being placed on the concept of healthy
aging rather than considering the total number of years lived. Although the concept of …

We previously quantified frailty in aged mice with frailty index (FI) that used specialized
equipment to measure health parameters. Here we developed a simplified, noninvasive …

Genome wide association studies (GWAS) rely on microarrays, or more recently mapping of
sequencing reads, to genotype individuals. The reliance on prior sequencing of a reference …

Background Hyperlipidemia and insulin resistance are risk factors for the development of
metabolic syndrome and cardiovascular disease. We have previously observed that …

The TOMM40‐APOE variants are known for their strong, antagonistic associations with
Alzheimer's disease and body weight. While a stronger role of the APOE than TOMM40 …

Abstract Xin-Ke-Shu (XKS) is a patent drug used for coronary heart diseases in China. This
study evaluated the protective effect of XKS against isoproterenol (ISO)-induced myocardial …

Abstract Machine learning has been applied to neuroimaging data for estimating brain age
and capturing early cognitive impairment in neurodegenerative diseases. Blood parameters …

Enduring interest in the Apolipoprotein E (ApoE) polymorphism is ensured by its
evolutionary-driven uniqueness in humans and its prominent role in geriatrics and …

The apolipoprotein E (apoE) is a classic example of a gene exhibiting pleiotropism. We
examine potential pleiotropic associations of the apoE2 allele in three biodemographic …