Sonic hedgehog (Shh) is a secreted protein with important roles in mammalian
embryogenesis. During tooth development, Shh is primarily expressed in the dental …

Sonic hedgehog (Shh) is an essential signaling peptide required for normal embryonic
development. It represents a highly-conserved marker of odontogenesis amongst the …

The WNT/β-CATENIN signaling has been demonstrated to play critical roles in mouse tooth
development, but little is known about the status of these molecules in human embryonic …

Tooth number anomalies, including hyperdontia and hypodontia, are common congenital
dental problems in the dental clinic. The precise number of teeth in a dentition is essential …

Presence of the pituitary adenylate cyclase-activating polypeptide (PACAP) signalling has
been proved in various peripheral tissues. PACAP can activate protein kinase A (PKA) …

Classic tissue recombination studies have demonstrated that, in the early developing mouse
tooth germ, the odontogenic potential, known as the tooth-inductive capability, resides …

Wallerian degeneration is a subject of major interest in neuroscience. A large number of
genes are differentially regulated during the distinct stages of Wallerian degeneration …

The developing murine tooth has been used as an excellent model system to study the
molecular mechanism of organ development and regeneration. While the expression …

Mammalian tooth development is regulated by paracrine signal molecules of several
conserved family interactions between epithelium and mesenchyme. The expression …

Odontogenesis is a complex process, where disruption can result in dental anomalies
and/or increase the risk of developing dental caries. Based on previous studies, certain …