Anti-inflammatory and immunoregulatory action of sesquiterpene lactones

A Paço, T Brás, JO Santos, P Sampaio, AC Gomes… - Molecules, 2022 - mdpi.com
Sesquiterpene lactones (SL), characterized by their high prevalence in the Asteraceae
family, are one of the major groups of secondary metabolites found in plants. Researchers …

[HTML][HTML] Sustainable Extraction of Bioactive Compounds and Nutrients from Agri-Food Wastes: Potential Reutilization of Berry, Honey, and Chicory Byproducts

G Peron, I Ferrarese, N Carmo Dos Santos, F Rizzo… - Applied Sciences, 2024 - mdpi.com
Several agri-food byproducts represent valuable sources of compounds to be reutilized for
nutritional, nutraceutical, and cosmetic purposes. Examples especially comprise byproducts …

Chicory extracts and sesquiterpene lactones show potent activity against bacterial and fungal pathogens

ST Häkkinen, M Soković, L Nohynek, A Ćirić, M Ivanov… - Pharmaceuticals, 2021 - mdpi.com
Chicory (Cichorium intybus L.) is an important industrial crop cultivated mainly to extract the
dietary fiber inulin. However, chicory also contains bioactive compounds such as …

[HTML][HTML] Bacteroides salyersiae Is a Candidate Probiotic Species with Potential Anti-Colitis Properties in the Human Colon: First Evidence from an In Vivo Mouse …

W Dai, Y Lv, M Quan, M Ma, Q Shang, G Yu - Nutrients, 2024 - mdpi.com
Previous studies have indicated a critical role of intestinal bacteria in the pathogenesis of
ulcerative colitis (UC). B. salyersiae is a commensal species from the human gut microbiota …

Lactucin Synthase Inactivation Boosts the Accumulation of Anti-inflammatory 8-Deoxylactucin and Its Derivatives in Chicory (Cichorium intybus L.)

K Cankar, JC Hakkert, R Sevenier… - Journal of Agricultural …, 2023 - ACS Publications
For several sesquiterpene lactones (STLs) found in Asteraceae plants, very interesting
biomedical activities have been demonstrated. Chicory roots accumulate the guaianolide …

A Three-Step Process to Isolate Large Quantities of Bioactive Sesquiterpene Lactones from Cichorium intybus L. Roots and Semisynthesis of Chicory STLs Standards

F Ruggieri, P Hance, B Gioia, A Biela, P Roussel… - Pharmaceuticals, 2023 - mdpi.com
Sesquiterpene lactones (STLs) are a large group of terpenoids most commonly found in
plants of the Asteraceae family, eg, in chicory plants, displaying a wide range of interesting …

[HTML][HTML] Anti-protozoal activity and metabolomic analyses of Cichorium intybus L. against Trypanosoma cruzi

M Peña-Espinoza, Y Romero-Uzqueda… - International Journal for …, 2022 - Elsevier
Chagas disease, caused by the protozoa Trypanosoma cruzi, is a potentially life-threatening
parasitic zoonosis infecting 6–7 million people worldwide, mainly in Latin America. Due to …

Environmental and socio-economic impacts of new plant breeding technologies: A case study of root chicory for inulin production

M Hingsamer, V Kulmer, M de Roode… - Frontiers in Genome …, 2022 - frontiersin.org
In Europe, root chicory and other plants are cultivated for their prebiotic food fiber, inulin,
which boosts the growth of beneficial gut bacteria and stimulates the human immune …

Targeting proteases involved in the viral replication of SARS-CoV-2 by sesquiterpene lactones from chicory (Cichorium intybus L.)

MÁ Ávila-Gálvez, C Rafael-Pita, N Fernández… - Food & Function, 2022 - pubs.rsc.org
SARS-CoV-2 is a highly transmissible and pathogenic coronavirus causing a respiratory
disease that emerged in 2019, leading to a public health emergency situation which …

Centipeda minima extracts and the active sesquiterpene lactones have therapeutic efficacy in non-small cell lung cancer by suppressing Skp2/p27 signaling pathway

HC Wang, PE Wu, WD He, CY Chen, RQ Zheng… - Journal of …, 2025 - Elsevier
Ethnophamacological relevance Centipeda minima (L.) A. Braun & Asch (C. minima) was
applied to treat nasal allergy, headache, cough, and even nasopharyngeal carcinoma in …