The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics

L Qian, X Lin, X Gao, RU Khan, JY Liao, S Du… - Chemical …, 2023 - ACS Publications
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

An overview of dynamic covalent bonds in polymer material and their applications

S Huang, X Kong, Y Xiong, X Zhang, H Chen… - European Polymer …, 2020 - Elsevier
Dynamic covalent bonds (DCBs) have received widespread attention due to their unique
reversibility and stimulus responsiveness. The introduction of DCBs often endows materials …

Disulfide-mediated reversible polymerization toward intrinsically dynamic smart materials

Q Zhang, DH Qu, BL Feringa… - Journal of the American …, 2022 - ACS Publications
The development of a dynamic chemistry toolbox to endow materials dynamic behavior has
been key to the rational design of future smart materials. The rise of supramolecular and …

Controlled-Radical Polymerization of α-Lipoic Acid: A General Route to Degradable Vinyl Copolymers

KR Albanese, PT Morris, J Read de Alaniz… - Journal of the …, 2023 - ACS Publications
Here, we present the synthesis and characterization of statistical and block copolymers
containing α-lipoic acid (LA) using reversible addition–fragmentation chain-transfer (RAFT) …

Acid‐catalyzed Disulfide‐mediated Reversible Polymerization for Recyclable Dynamic Covalent Materials

BS Wang, Q Zhang, ZQ Wang, CY Shi… - Angewandte Chemie …, 2023 - Wiley Online Library
Abstract Poly (1, 2‐dithiolane) s are a family of intrinsically recyclable polymers due to their
dynamic covalent disulfide linkages. Despite the common use of thiolate‐initiated anionic …

Cationic polysaccharide conjugates as antibiotic adjuvants resensitize multidrug‐resistant bacteria and prevent resistance

S Mu, Y Zhu, Y Wang, S Qu, Y Huang… - Advanced …, 2022 - Wiley Online Library
In recent years, traditional antibiotic efficacy has rapidly diminished due to the advent of
multidrug‐resistant (MDR) bacteria, which poses severe threat to human life and globalized …

Improving cellular uptake of therapeutic entities through interaction with components of cell membrane

R Zhang, X Qin, F Kong, P Chen, G Pan - Drug Delivery, 2019 - Taylor & Francis
Efficient cellular delivery of biologically active molecules is one of the key factors that affect
the discovery and development of novel drugs. The plasma membrane is the first barrier that …

Rational design of nanocarriers for intracellular protein delivery

X Qin, C Yu, J Wei, L Li, C Zhang, Q Wu… - Advanced …, 2019 - Wiley Online Library
Protein/antibody therapeutics have exhibited the advantages of high specificity and activity
even at an extremely low concentration compared to small molecule drugs. However, they …

Polymeric Nanoparticles for Drug Delivery

MA Beach, U Nayanathara, Y Gao, C Zhang… - Chemical …, 2024 - ACS Publications
The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …

Thiol-mediated uptake

Q Laurent, R Martinent, B Lim, AT Pham, T Kato… - Jacs Au, 2021 - ACS Publications
This Perspective focuses on thiol-mediated uptake, that is, the entry of substrates into cells
enabled by oligochalcogenides or mimics, often disulfides, and inhibited by thiol-reactive …