Growth-associated protein-43 (GAP-43) and brain acid-soluble protein 1 (BASP1) regulate
actin dynamics and presynaptic vesicle cycling at axon terminals, thereby facilitating axonal …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

The signals that promote regional growth and development of the brain are not well
understood. Sonic hedgehog (Shh) is produced by Purkinje cells of the cerebellum and is a …

In contrast to peripheral nerves, damaged axons in the mammalian brain and spinal cord
rarely regenerate. Peripheral nerve injury stimulates neuronal expression of many genes …

The cerebellar cortex and its sole output, the Purkinje cell, have been implicated in motor
coordination, learning and cognitive functions. Therefore, the ability to generate Purkinje cell …

The failure of axons to regenerate after spinal cord injury remains one of the greatest
challenges facing both medicine and neuroscience, but in the last 20 years there have been …

Inhibition by several inhibitory molecules on oligodendrocytes, and by chondroitin sulphate
proteoglycans and semaphorins in the glial scar discourages regeneration of axons in the …

We compared the effects of intravitreal injection of bi-cistronic adeno-associated viral (AAV-
2) vectors encoding enhanced green fluorescent protein (GFP) and either ciliary …

Background and Purpose—An objective of therapeutic intervention after cerebral ischemia
is to promote improved functional outcome. Improved outcome may be associated with a …

Abstract Background The Myristoylated Alanine-Rich C-kinase Substrate (MARCKS) and
MARCKS-like protein 1 (MARCKSL1) have a wide range of functions, ranging from roles in …