Transcription factors (TFs) play a crucial role in regulating the dynamic and precise patterns
of gene expression required for the initial specification of endothelial cells (ECs), and during …

Ischemic cardiovascular disease still remains as a leading cause of morbidity and mortality
despite various medical, surgical, and interventional therapy. As such, cell therapy has …

Cardiac lymphatic vessels play important roles in fluid homeostasis, inflammation, disease,
and regeneration of the heart. The developing cardiac lymphatics in human fetal hearts are …

Background B-cell CLL/lymphoma 6 member B (BCL6B) operates as a sequence-specific
transcriptional repressor within the nucleus, playing crucial roles in various biological …

Many transcription factors (TFs) function as tumor suppressor genes with heterozygous
phenotypes, yet haploinsufficiency generally has an underappreciated role in neoplasia …

Introduction: Generating new lymphatic vessels has been postulated as an innovative
therapeutic strategy for various disease phenotypes, including neurodegenerative diseases …

BACKGROUND: The resiliency of embryonic development to genetic and environmental
perturbations has been long appreciated; however, little is known about the mechanisms …

Cardiovascular system develops from the lateral plate mesoderm. Its three primary cell
lineages (hematopoietic, endothelial, and muscular) are specified by the sequential actions …

Cord blood (CB) CD34+ cells have the potential to be used to achieve artificial
hematopoiesis because of their ability to expand and differentiate in multiple directions …

Mechanisms underlying distinct specification, commitment, and differentiation phases of cell
fate determination remain undefined due to difficulties capturing these processes. Here, we …