The landscape of aging
Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
[HTML][HTML] The Interplay of Protein Aggregation, Genetics, and Oxidative Stress in Alzheimer's Disease: Role for Natural Antioxidants and Immunotherapeutics
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that comprises
amyloid-beta protein (Aβ) as a main component of neuritic plaques. Its deposition is …
amyloid-beta protein (Aβ) as a main component of neuritic plaques. Its deposition is …
Microglia-like cells promote neuronal functions in cerebral organoids
I Fagerlund, A Dougalis, A Shakirzyanova… - Cells, 2021 - mdpi.com
Human cerebral organoids, derived from induced pluripotent stem cells, offer a unique in
vitro research window to the development of the cerebral cortex. However, a key player in …
vitro research window to the development of the cerebral cortex. However, a key player in …
Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model
The use of iPSC derived brain organoid models to study neurodegenerative disease has
been hampered by a lack of systems that accurately and expeditiously recapitulate …
been hampered by a lack of systems that accurately and expeditiously recapitulate …
Reactive and senescent astroglial phenotypes as hallmarks of brain pathologies
A Lazic, V Balint, D Stanisavljevic Ninkovic… - International Journal of …, 2022 - mdpi.com
Astrocytes, as the most abundant glial cells in the central nervous system, are tightly
integrated into neural networks and participate in numerous aspects of brain physiology and …
integrated into neural networks and participate in numerous aspects of brain physiology and …
Development of brain organoid technology derived from iPSC for the neurodegenerative disease modelling: a glance through
Neurodegenerative diseases are adult-onset neurological conditions that are notoriously
difficult to model for drug discovery and development because most models are unable to …
difficult to model for drug discovery and development because most models are unable to …
Blood–brain barrier and neurovascular unit in vitro models for studying mitochondria-driven molecular mechanisms of neurodegeneration
AB Salmina, EV Kharitonova, YV Gorina… - International Journal of …, 2021 - mdpi.com
Pathophysiology of chronic neurodegeneration is mainly based on complex mechanisms
related to aberrant signal transduction, excitation/inhibition imbalance, excitotoxicity …
related to aberrant signal transduction, excitation/inhibition imbalance, excitotoxicity …
The emerging scenario of the gut–brain axis: the therapeutic actions of the new actor kefir against neurodegenerative diseases
TMC Pereira, LZ Côco, AMM Ton, SS Meyrelles… - Antioxidants, 2021 - mdpi.com
The fact that millions of people worldwide suffer from Alzheimer's disease (AD) or
Parkinson's disease (PD), the two most prevalent neurodegenerative diseases (NDs), has …
Parkinson's disease (PD), the two most prevalent neurodegenerative diseases (NDs), has …
Towards personalized allele-specific antisense oligonucleotide therapies for toxic gain-of-function neurodegenerative diseases
Antisense oligonucleotides (ASOs) are single-stranded nucleic acid strings that can be used
to selectively modify protein synthesis by binding complementary (pre-) mRNA sequences …
to selectively modify protein synthesis by binding complementary (pre-) mRNA sequences …
Interfacing brain organoids with precision medicine and machine learning
The brain is a complex organ that plays a central role in human activities. Brain organoid
modeling is an advanced technique for studying brain development, physiology, function …
modeling is an advanced technique for studying brain development, physiology, function …