Single-photon detection for long-range imaging and sensing

RH Hadfield, J Leach, F Fleming, DJ Paul, CH Tan… - Optica, 2023 - opg.optica.org
Single-photon detectors with picosecond timing resolution have advanced rapidly in the past
decade. This has spurred progress in time-correlated single-photon counting applications …

The new era of high-throughput nanoelectrochemistry

X Xu, D Valavanis, P Ciocci, S Confederat… - Analytical …, 2023 - ACS Publications
To acquire a deeper understanding of electrochemical systems requires techniques that
address nanoscale aspects of electrochemistry, inter alia, the detection and analysis of …

Precision size and refractive index analysis of weakly scattering nanoparticles in polydispersions

AD Kashkanova, M Blessing, A Gemeinhardt… - Nature …, 2022 - nature.com
Abstract Characterization of the size and material properties of particles in liquid
suspensions is in very high demand, for example, in the analysis of colloidal samples or of …

Scattering-based light microscopy: from metal nanoparticles to single proteins

L Priest, JS Peters, P Kukura - Chemical reviews, 2021 - ACS Publications
Our ability to detect, image, and quantify nanoscopic objects and molecules with visible light
has undergone dramatic improvements over the past few decades. While fluorescence has …

Bond-selective imaging by optically sensing the mid-infrared photothermal effect

Y Bai, J Yin, JX Cheng - Science advances, 2021 - science.org
Mid-infrared (IR) spectroscopic imaging using inherent vibrational contrast has been broadly
used as a powerful analytical tool for sample identification and characterization. However …

Optical technologies for the detection of viruses like COVID-19: Progress and prospects

J Lukose, S Chidangil, SD George - Biosensors and Bioelectronics, 2021 - Elsevier
The outbreak of life-threatening pandemic like COVID-19 necessitated the development of
novel, rapid and cost-effective techniques that facilitate detection of viruses like SARS-CoV …

Mass photometric detection and quantification of nanoscale α-synuclein phase separation

S Ray, TO Mason, L Boyens-Thiele, A Farzadfard… - Nature …, 2023 - nature.com
Protein liquid–liquid phase separation can lead to disease-related amyloid fibril formation.
The mechanisms of conversion of monomeric protein into condensate droplets and of the …

Self-supervised machine learning pushes the sensitivity limit in label-free detection of single proteins below 10 kDa

M Dahmardeh, H Mirzaalian Dastjerdi, H Mazal… - Nature …, 2023 - nature.com
Interferometric scattering (iSCAT) microscopy is a label-free optical method capable of
detecting single proteins, localizing their binding positions with nanometer precision, and …

Roadmap on Label‐Free Super‐Resolution Imaging

VN Astratov, YB Sahel, YC Eldar… - Laser & Photonics …, 2023 - Wiley Online Library
Label‐free super‐resolution (LFSR) imaging relies on light‐scattering processes in
nanoscale objects without a need for fluorescent (FL) staining required in super‐resolved FL …

Optical Monitoring of In Situ Iron Loading into Single, Native Ferritin Proteins

A Yousefi, C Ying, CDJ Parmenter, M Assadipapari… - Nano Letters, 2023 - ACS Publications
Ferritin is a protein that stores and releases iron to prevent diseases associated with iron
dysregulation in plants, animals, and bacteria. The conversion between iron-loaded holo …