Recent advances in mass spectrometry-based computational metabolomics
The computational metabolomics field brings together computer scientists, bioinformaticians,
chemists, clinicians, and biologists to maximize the impact of metabolomics across a wide …
chemists, clinicians, and biologists to maximize the impact of metabolomics across a wide …
Connecting chemical exposome to human health using high‐resolution mass spectrometry‐based biomonitoring: Recent advances and future perspectives
YC Chen, JF Hsu, CW Chang, SW Li… - Mass Spectrometry …, 2023 - Wiley Online Library
Compared with the rapid advances in genomics leading to broad understanding of human
disease, the linkage between chemical exposome and diseases is still under investigation …
disease, the linkage between chemical exposome and diseases is still under investigation …
Identification of formaldehyde-induced DNA–RNA cross-links in the A/J mouse lung tumorigenesis model
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent lung carcinogen present in
tobacco products, and exposure to it is likely one of the factors contributing to the …
tobacco products, and exposure to it is likely one of the factors contributing to the …
Biosynthesis and bioactivities of microbial genotoxin colibactins
Covering: up to 2021 Colibactin (s), a group of secondary metabolites produced by the pks
island (clb cluster) of Escherichia coli, shows genotoxicity relevant to colorectal cancer and …
island (clb cluster) of Escherichia coli, shows genotoxicity relevant to colorectal cancer and …
A Novel Adductomics Workflow Incorporating FeatureHunter Software: Rapid Detection of Nucleic Acid Modifications for Studying the Exposome
Exposure to the physicochemical agents that interact with nucleic acids (NA) may lead to
modification of DNA and RNA (ie, NA modifications), which have been associated with …
modification of DNA and RNA (ie, NA modifications), which have been associated with …
Nucleic acid adductomics–The next generation of adductomics towards assessing environmental health risks
This Discussion article aims to explore the potential for a new generation of assay to emerge
from cellular and urinary DNA adductomics which brings together DNA-RNA-and, to some …
from cellular and urinary DNA adductomics which brings together DNA-RNA-and, to some …
Mass spectrometry-based DNA adductomics
DNA adducts can be induced by both endogenous and external sources. Qualitative and
quantitative characterizations of DNA adducts are crucial to understanding their roles in the …
quantitative characterizations of DNA adducts are crucial to understanding their roles in the …
Liquid Chromatography–Mass Spectrometry Screening of Cyclophosphamide DNA Damage In Vitro and in Patients Undergoing Chemotherapy Treatment
V Guidolin, FC Jacobs, ML MacMillan… - Chemical research in …, 2023 - ACS Publications
DNA alkylating drugs have been used as frontline medications to treat cancer for decades.
Their chemical reaction with DNA leads to the blockage of DNA replication, which impacts …
Their chemical reaction with DNA leads to the blockage of DNA replication, which impacts …
Current and future methodology for quantitation and site-specific mapping the location of DNA adducts
Formation of DNA adducts is a key event for a genotoxic mode of action, and their presence
is often used as a surrogate for mutation and increased cancer risk. Interest in DNA adducts …
is often used as a surrogate for mutation and increased cancer risk. Interest in DNA adducts …
Multi-adductomics: Advancing mass spectrometry techniques for comprehensive exposome characterization
Adductomics, an emerging field within the'omics sciences, focuses on the formation and
prevalence of DNA, RNA, and protein adducts induced by endogenous and exogenous …
prevalence of DNA, RNA, and protein adducts induced by endogenous and exogenous …