Intestinal mucus and their glycans: A habitat for thriving microbiota

AS Luis, GC Hansson - Cell Host & Microbe, 2023 - cell.com
The colon mucus layer is organized with an inner colon mucus layer that is impenetrable to
bacteria and an outer mucus layer that is expanded to allow microbiota colonization. A major …

Global functions of O‐glycosylation: promises and challenges in O‐glycobiology

HH Wandall, MAI Nielsen, S King‐Smith… - The FEBS …, 2021 - Wiley Online Library
Mucin type O‐glycosylation is one of the most diverse types of glycosylation, playing
essential roles in tissue development and homeostasis. In complex organisms, O‐GalNAc …

Golgi pH, ion and redox homeostasis: how much do they really matter?

S Kellokumpu - Frontiers in cell and developmental biology, 2019 - frontiersin.org
Exocytic and endocytic compartments each have their own unique luminal ion and pH
environment that is important for their normal functioning. A failure to maintain this …

The disulfide catalyst QSOX1 maintains the colon mucosal barrier by regulating Golgi glycosyltransferases

T Ilani, N Reznik, N Yeshaya, T Feldman, P Vilela… - The EMBO …, 2023 - embopress.org
Mucus is made of enormous mucin glycoproteins that polymerize by disulfide crosslinking in
the Golgi apparatus. QSOX1 is a catalyst of disulfide bond formation localized to the Golgi …

GALNTs: master regulators of metastasis-associated epithelial-mesenchymal transition (EMT)?

EM Beaman, DRF Carter, SA Brooks - Glycobiology, 2022 - academic.oup.com
In humans, the UDP-N-α-D galactosamine: polypeptide N-acetylgalactosaminyltransferases
family (ppGalNAc-Ts, GalNAc-Ts or GALNTs) comprises 20 isoenzymes. They are …

Golgi inCOGnito: From vesicle tethering to human disease

Z D'Souza, FS Taher, VV Lupashin - Biochimica et Biophysica Acta (BBA) …, 2020 - Elsevier
Abstract The Conserved Oligomeric Golgi (COG) complex, a multi-subunit vesicle tethering
complex of the CATCHR (Complexes Associated with Tethering Containing Helical Rods) …

[HTML][HTML] The glyco-redox interplay: Principles and consequences on the role of reactive oxygen species during protein glycosylation

F Khoder-Agha, T Kietzmann - Redox Biology, 2021 - Elsevier
Reactive oxygen species (ROS) carry out prime physiological roles as intracellular signaling
agents, yet pathologically high concentrations of ROS cause irreversible damage to …

The vertebrate sialylation machinery: structure-function and molecular evolution of GT-29 sialyltransferases

A Harduin-Lepers - Glycoconjugate Journal, 2023 - Springer
Every eukaryotic cell is covered with a thick layer of complex carbohydrates with essential
roles in their social life. In Deuterostoma, sialic acids present at the outermost positions of …

Genome-wide association study and genomic prediction of tolerance to acute hypoxia in rainbow trout

M Prchal, J D'Ambrosio, H Lagarde, D Lallias, P Patrice… - Aquaculture, 2023 - Elsevier
Hypoxia is one of the major threats to the aquaculture sector resulting in substantial
economic losses to the fish farmers. Thus, tolerance to hypoxia is of high economic interest …

Enrichment and fragmentation approaches for enhanced detection and characterization of endogenous glycosylated neuropeptides

A Phetsanthad, C Roycroft, L Li - Proteomics, 2023 - Wiley Online Library
Glycosylated neuropeptides were recently discovered in crustaceans, a model organism
with a well‐characterized neuroendocrine system. Several workflows exist to characterize …