Conformations of immunoglobulin hypervariable regions

C Chothia, AM Lesk, A Tramontano, M Levitt… - Nature, 1989 - nature.com
On the basis of comparative studies of known antibody structures and sequences it has
been argued that there is a small repertoire of main-chain conformations for at least five of …

Knowledge-based prediction of protein structures and the design of novel molecules

TL Blundell, BL Sibanda, MJE Sternberg, JM Thornton - Nature, 1987 - nature.com
Prediction of the tertiary structures of proteins may be carried out using a knowledge-based
approach. This depends on identification of analogies in secondary structures, motifs …

Canonical structures for the hypervariable regions of immunoglobulins

C Chothia, AM Lesk - Journal of molecular biology, 1987 - Elsevier
We have analysed the atomic structures of Fab and VL fragments of immunoglobulins to
determine the relationship between their amino acid sequences and the three-dimensional …

Modeling of loops in protein structures

A Fiser, RKG Do, A Šali - Protein science, 2000 - Wiley Online Library
Comparative protein structure prediction is limited mostly by the errors in alignment and loop
modeling. We describe here a new automated modeling technique that significantly …

Antibody-antigen interactions: contact analysis and binding site topography

RM MacCallum, ACR Martin, JM Thornton - Journal of molecular biology, 1996 - Elsevier
We have analysed antigen-contacting residues and combining site shape in the antibody Fv
and Fab crystal structures now available from the Protein Data Bank. Antigen-contacting …

Standard conformations for the canonical structures of immunoglobulins

B Al-Lazikani, AM Lesk, C Chothia - Journal of molecular biology, 1997 - Elsevier
A comparative analysis of the main-chain conformation of the L1, L2, L3, H1 and H2
hypervariable regions in 17 immunoglobulin structures that have been accurately …

Three-dimensional structure of an antigen-antibody complex at 2.8 Å resolution

AG Amit, RA Mariuzza, SEV Phillips, RJ Poljak - Science, 1986 - science.org
The 2.8 Å resolution three-dimensional structure of a complex between an antigen
(lysozyme) and the Fab fragment from a monoclonal antibody against lysozyme has been …

Structural repertoire of the human VH segments

C Chothia, AM Lesk, E Gherardi, IM Tomlinson… - Journal of molecular …, 1992 - Elsevier
The VH gene segments produce the part of the VH domains of antibodies that contains the
first two hypervariable regions. The sequences of 83 human VH segments with open …

The structural basis of antigen-antibody recognition.

RA Mariuzza, SE Phillips, RJ Poljak - Annual review of biophysics …, 1987 - europepmc.org
We have reviewed here the three-dimensional structure of an antigen-Fab complex as
determined by X-ray crystallographic studies. The antigen is hen egg-white lysozyme (HEL) …

Structural factors that control conformational transitions and serotype specificity in type 3 poliovirus.

DJ Filman, R Syed, M Chow, AJ Macadam… - The EMBO …, 1989 - embopress.org
The three‐dimensional structure of the Sabin strain of type 3 poliovirus has been determined
at 2.4 A resolution. Significant structural differences with the Mahoney strain of type 1 …