Antifungal resistance, metabolic routes as drug targets, and new antifungal agents: an overview about endemic dimorphic fungi

JA Parente-Rocha, AM Bailão… - Mediators of …, 2017 - Wiley Online Library
Diseases caused by fungi can occur in healthy people, but immunocompromised patients
are the major risk group for invasive fungal infections. Cases of fungal resistance and the …

Intranasal vaccine using P10 peptide complexed within chitosan polymeric nanoparticles as experimental therapy for paracoccidioidomycosis in murine model

S Rodrigues Dos Santos Junior… - Journal of Fungi, 2020 - mdpi.com
Paracoccidioidomycosis (PCM) is a granulomatous fungal disease caused by the dimorphic
fungal species of Paracoccidioides, which mainly affects the lungs. Modern strategies for the …

Paracoccidioides brasiliensis Vaccine Formulations Based on the gp43-Derived P10 Sequence and the Salmonella enterica FliC Flagellin

CJM Braga, GMG Rittner, JE Munoz Henao… - Infection and …, 2009 - Am Soc Microbiol
Paracoccidioidomycosis (PCM) is a systemic granulomatous disease caused by the
dimorphic fungus Paracoccidioides brasiliensis. Anti-PCM vaccine formulations based on …

Therapeutic Administration of Recombinant Paracoccin Confers Protection against Paracoccidioides brasiliensis Infection: Involvement of TLRs

ACP Alegre-Maller, FC Mendonça… - PLoS neglected …, 2014 - journals.plos.org
Background Paracoccin (PCN) is an N-acetylglucosamine-binding lectin from the human
pathogenic fungus Paracoccidioides brasiliensis. Recombinant PCN (rPCN) induces a T …

[HTML][HTML] Therapeutic treatment with scFv–PLGA nanoparticles decreases pulmonary fungal load in a murine model of paracoccidioidomycosis

GP Jannuzzi, N de Araújo Souza, KS Françoso… - Microbes and …, 2018 - Elsevier
Paracoccidioidomycosis (PCM) is a systemic mycosis with lymphatic dissemination that is
caused by Paracoccidioides species. Treatment of PCM consists of chemotherapeutics such …

New advances in the development of a vaccine against paracoccidioidomycosis

LR Travassos, CP Taborda - Frontiers in Microbiology, 2012 - frontiersin.org
Paracoccidioidomycosis (PCM) is an endemic Latin American mycosis caused by
Paracoccidioides brasiliensis and also by the recently described P. lutzii. The systemic …

Protective immunity induced by rPb27 of Paracoccidioides brasiliensis

BS Reis, VC Fernandes, EMN Martins, R Serakides… - Vaccine, 2008 - Elsevier
A cDNA coding for an antigenic protein (rPb27) from the pathogenic fungus
Paracoccidioides brasiliensis was cloned and its protective activity was determined against …

Recombinant vaccines of a CD4+ T-cell epitope promote efficient control of Paracoccidioides brasiliensis burden by restraining primary organ infection

RA Holanda, JE Muñoz, LS Dias… - PLOS Neglected …, 2017 - journals.plos.org
Paracoccidioidomycosis (PCM) is an infectious disease endemic to South America, caused
by the thermally dimorphic fungi Paracoccidioides. Currently, there is no effective human …

Real time polymerase chain reaction (rt-PCR): a new patent to diagnostic purposes for paracoccidioidomycosis

F Rocha-Silva, L I. Gomes… - Recent Patents on …, 2016 - benthamdirect.com
Background: Paracoccidioidomycosis (PCM) is a systemic mycosis caused by dimorphic
fungi Paracoccidioides brasiliensis and Paracoccidioides lutzii. It is prevalent in Latin …

[HTML][HTML] The combined use of Paracoccidioides brasiliensis Pb40 and Pb27 recombinant proteins enhances chemotherapy effects in experimental …

VC Fernandes, EMN Martins, JN Boeloni… - Microbes and …, 2011 - Elsevier
Paracoccidioides brasiliensis is the etiological agent of paracoccidioidomycosis (PCM), a
chronic granulomatous mycosis prevalent in Latin America, and cell-mediated immunity …