Tumour burden and efficacy of immune-checkpoint inhibitors

FG Dall'Olio, A Marabelle, C Caramella… - Nature reviews Clinical …, 2022 - nature.com
Accumulating evidence suggests that a high tumour burden has a negative effect on
anticancer immunity. The concept of tumour burden, simply defined as the total amount of …

Current and future clinical applications of ctDNA in immuno-oncology

JC Stadler, Y Belloum, B Deitert, M Sementsov… - Cancer Research, 2022 - AACR
Testing peripheral blood for circulating tumor DNA (ctDNA) offers a minimally invasive
opportunity to diagnose, characterize, and monitor the disease in individual cancer patients …

[HTML][HTML] Non-small cell lung carcinoma (NSCLC): Implications on molecular pathology and advances in early diagnostics and therapeutics

H Padinharayil, J Varghese, MC John, GK Rajanikant… - Genes & …, 2023 - Elsevier
Continuous revision of the histologic and stage-wise classification of lung cancer by the
World Health Organization (WHO) provides the foundation for therapeutic advances by …

Liquid biopsy in non-small cell lung cancer: highlights and challenges

E Rijavec, S Coco, C Genova, G Rossi, L Longo… - Cancers, 2019 - mdpi.com
Non-small cell lung cancer is one leading cause of death worldwide, and patients would
greatly benefit from an early diagnosis. Since targeted and immunotherapies have emerged …

Immunotherapy in nonsmall-cell lung cancer: current status and future prospects for liquid biopsy

EM Brozos-Vázquez, R Díaz-Peña… - Cancer Immunology …, 2021 - Springer
Immunotherapy has been one of the great advances in the recent years for the treatment of
advanced tumors, with nonsmall-cell lung cancer (NSCLC) being one of the cancers that …

Liquid biopsy on the horizon in immunotherapy of non-small cell lung cancer: current status, challenges, and perspectives

Y Yang, H Liu, Y Chen, N Xiao, Z Zheng, H Liu… - Cell Death & …, 2023 - nature.com
Non-small cell lung cancer (NSCLC) is one of the most threatening malignancies to human
health and life. In most cases, patients with NSCLC are already at an advanced stage when …

Prognostic role of soluble and extracellular vesicle-associated PD-L1, B7-H3 and B7-H4 in non-small cell lung cancer patients treated with immune checkpoint …

C Genova, R Tasso, A Rosa, G Rossi, D Reverberi… - Cells, 2023 - mdpi.com
The treatment of non-small cell lung cancer (NSCLC) has changed dramatically with the
advent of immune checkpoint inhibitors (ICIs). Despite encouraging results, their efficacy …

The role of circulating biomarkers in lung cancer

S Herath, H Sadeghi Rad, P Radfar, R Ladwa… - Frontiers in …, 2022 - frontiersin.org
Lung cancer is the leading cause of cancer morbidity and mortality worldwide and early
diagnosis is crucial for the management and treatment of this disease. Non-invasive means …

Precision medicine for NSCLC in the era of immunotherapy: new biomarkers to select the most suitable treatment or the most suitable patient

G Rossi, A Russo, M Tagliamento, A Tuzi, O Nigro… - Cancers, 2020 - mdpi.com
In recent years, the evolution of treatments has made it possible to significantly improve the
outcomes of patients with non-small cell lung cancer (NSCLC). In particular, while molecular …

Circulating biomarkers of response and toxicity of immunotherapy in advanced non-small cell lung cancer (NSCLC): a comprehensive review

A Indini, E Rijavec, F Grossi - Cancers, 2021 - mdpi.com
Simple Summary Although immunotherapy has dramatically revolutionized non-small cell
lung cancer (NSCLC) treatment, not all the patients will benefit from this innovative therapy …