Abstract The Ca2+-sensing receptor (CaSR) is a dimeric family CG protein-coupled receptor
that is expressed in calcitropic tissues such as the parathyroid glands and the kidneys and …

Developmental lung biology is a field that has the potential for significant human impact:
lung disease at the extremes of age continues to cause major morbidity and mortality …

Compelling evidence of a cell surface receptor sensitive to extracellular calcium was
observed as early as the 1980s and was finally realized in 1993 when the calcium-sensing …

Airway structure and function are key aspects of normal lung development, growth, and
aging, as well as of lung responses to the environment and the pathophysiology of important …

The calcium-sensing receptor (CaSR) is a G protein-coupled receptor whose function can
be allosterically modulated in a positive or negative manner by calcimimetics or calcilytics …

The extracellular calcium-sensing receptor (CaSR) is the first identified G protein–coupled
receptor to be activated by an ion, extracellular calcium (Ca2+). Since the identification of …

Rationale: A rise in cytosolic Ca2+ concentration ([Ca2+] cyt) in pulmonary arterial smooth
muscle cells (PASMC) is an important stimulus for pulmonary vasoconstriction and vascular …

Background Previously, we identified a major quantitative trait locus (QTL) for host response
to Porcine Respiratory and Reproductive Syndrome virus (PRRSV) infection in high linkage …

γ-Glutamyl peptides were identified previously as novel positive allosteric modulators of Ca
2+ o-dependent intracellular Ca 2+ mobilization in HEK-293 cells that bind in the calcium …

Optimal fetal lung growth requires anion-driven fluid secretion into the lumen of the
developing organ. The fetus is hypercalcemic compared to the mother and here we show …