How do we reconcile echocardiography, computed tomography, and hybrid imaging in assessing discordant grading of aortic stenosis severity?
Up to 40% of patients with aortic stenosis (AS) present with a “discordant grading” usually
referred to as “low-gradient AS.” This article presents a step-by-step integrative approach …
referred to as “low-gradient AS.” This article presents a step-by-step integrative approach …
Hypertension in aortic stenosis: a focused review and recommendations for clinical practice
S Saeed, F Scalise, JB Chambers… - Journal of …, 2020 - journals.lww.com
In patients with aortic stenosis, the presence of hypertension negatively affects the
hemodynamic severity of the stenosis, and worsens adverse left ventricular remodeling. It …
hemodynamic severity of the stenosis, and worsens adverse left ventricular remodeling. It …
Transvalvular flow rate determines prognostic value of aortic valve area in aortic stenosis
M Namasivayam, W He, TW Churchill… - journal of the American …, 2020 - jacc.org
Background Aortic valve area (AVA)≤ 1.0 cm2 is a defining characteristic of severe aortic
stenosis (AS). AVA can be underestimated at low transvalvular flow rate. Yet, the impact of …
stenosis (AS). AVA can be underestimated at low transvalvular flow rate. Yet, the impact of …
The impact of aortic valve replacement on survival in patients with normal flow low gradient severe aortic stenosis: a propensity-matched comparison
S Saeed, A Vamvakidou, R Seifert… - European Heart …, 2019 - academic.oup.com
Aims To assess the survival benefit of aortic valve replacement (AVR) in patients with normal
flow low gradient severe aortic stenosis (AS). Methods and results A retrospective study of …
flow low gradient severe aortic stenosis (AS). Methods and results A retrospective study of …
First-phase ejection fraction is a powerful predictor of adverse events in asymptomatic patients with aortic stenosis and preserved total ejection fraction
H Gu, S Saeed, A Boguslavskyi, G Carr-White… - JACC: Cardiovascular …, 2019 - jacc.org
Objectives: This study investigated the prognostic value of first-phase ejection fraction (EF1)
in patients with aortic stenosis (AS), a condition in which left ventricular dysfunction as …
in patients with aortic stenosis (AS), a condition in which left ventricular dysfunction as …
Low transvalvular flow rate predicts mortality in patients with low-gradient aortic stenosis following aortic valve intervention
A Vamvakidou, W Jin, O Danylenko, N Chahal… - JACC: Cardiovascular …, 2019 - jacc.org
Objectives: This study aimed to assess the value of low transvalvular flow rate (FR) for the
prediction of mortality compared with low stroke volume index (SVi) in patients with low …
prediction of mortality compared with low stroke volume index (SVi) in patients with low …
Sex differences in aortic stenosis: from pathophysiology to treatment
S Saeed, MR Dweck, J Chambers - Expert review of cardiovascular …, 2020 - Taylor & Francis
Introduction: In aortic stenosis (AS), there are clear sex differences in clinical presentation,
left ventricular (LV) response to pressure overload, and pathophysiology of valvular …
left ventricular (LV) response to pressure overload, and pathophysiology of valvular …
[HTML][HTML] Determinants and clinical significance of aortic stiffness in patients with moderate or severe aortic stenosis
S Saeed, N Saeed, K Grigoryan, P Chowienczyk… - International Journal of …, 2020 - Elsevier
Background Patients with degenerative aortic stenosis (AS) are often older and have
systemic hypertension and atherosclerosis, which all lead to increased aortic stiffness. We …
systemic hypertension and atherosclerosis, which all lead to increased aortic stiffness. We …
Using discrete multiphysics modelling to assess the effect of calcification on hemodynamic and mechanical deformation of aortic valve
This study proposes a 3D particle-based (discrete) multiphysics approach for modelling
calcification in the aortic valve. Different stages of calcification (from mild to severe) were …
calcification in the aortic valve. Different stages of calcification (from mild to severe) were …
Exercise treadmill testing in moderate or severe aortic stenosis: the left ventricular correlates of an exaggerated blood pressure rise
Background Exaggerated blood pressure response during exercise predicts future
hypertension and cardiovascular events in general population and different patients groups …
hypertension and cardiovascular events in general population and different patients groups …