Several members of the short-chain dehydrogenase/reductase (SDR) enzyme family play
fundamental roles in adrenal and gonadal steroidogenesis as well as in the metabolism of …

Yeasts cope with a wide range of environmental challenges using different adaptive
mechanisms. They can prosper at extreme ambient pH and high temperatures; however …

Candida albicans can cause adverse infections in humans. The targeting of Sap 5 is due to
its virulence factor in C. albicans. The method used is molecular docking using YASARA …

Elucidating the interaction networks associated with secondary metabolite production in
microorganisms is an ongoing challenge made all the more daunting by the rate at which …

Hydroxy-or ketone-functionalized fatty acid methyl esters (FAMEs) are important compounds
for production of pharmaceuticals, vitamins, cosmetics or dietary supplements. Biocatalysis …

Positions identified in directed evolution campaigns or by (semi) rational design can be
recombined iteratively or simultaneously. Iterative recombination has yielded many success …

Two representative substrates, a ketone 2-hydroxyacetophenone (2HAP) and an α-ketoester
ethyl-2-oxo-4-phenylbutanoate (EOPB) are reduced by a purified (S)-specific carbonyl …

The zinc‐dependent medium‐chain alcohol dehydrogenase from Rhodococcus erythropolis
(ReADH) is one of the most versatile biocatalysts for the stereoselective reduction of ketones …

In protein engineering, investigations of catalytic cycle facilitate rational design of enzymes.
In the present work, deeper analysis on the catalytic cycle of malate enzyme (EC 1.1. 1.40) …

Expanding the substrate scope of enzymes opens up new routes for synthesis of valuable
chemicals. Ketone‐functionalized fatty acid derivatives and corresponding chiral alcohols …