Medullary Thyroid Carcinoma (MTC), a neuroendocrine malignancy that arises from the
calcitonin-secreting parafollicular C-cells of the thyroid, constitutes a minor yet impactful …

Design of the next-generation of therapeutics, biosensors, and molecular tools for basic
research requires that we bring protein activity under control. Each protein has unique …

The islets of Langerhans reside within the endocrine pancreas as highly vascularized
microorgans that are responsible for the secretion of key hormones, such as insulin and …

The use of bioluminescence as a reporter for physiology in neuroscience is as old as the
discovery of the calcium-dependent photon emission of aequorin. Over the years …

Signaling pathways orchestrate fundamental biological processes, including development,
regeneration, homeostasis, and disease. Methods to experimentally manipulate signaling …

Protein-protein interactions (PPIs) mediate many fundamental cellular processes and their
control through optically or chemically responsive protein domains has a profound impact on …

Brain-derived neurotrophic factor (BDNF)/Tropomyosin receptor kinase B (TrkB) signaling is
pivotal for the survival, proliferation, and differentiation of neuronal cells. TrkB is a member of …

Bladder cancer is a complex disease with distinct treatment approaches based on its
progression. For non-muscle invasive bladder cancer, the primary treatment method …