Vascular endothelial growth factors (VEGFs) are best known for their involvement in
orchestrating the development and maintenance of the blood and lymphatic vascular …

The generation of new lymphatic vessels through lymphangiogenesis and the remodelling
of existing lymphatics are thought to be important steps in cancer metastasis. The past …

Neutrophil extracellular traps (NETs), which consist of chromatin DNA filaments coated with
granule proteins, are released by neutrophils to trap microorganisms,–. Recent studies have …

Blood vessels deliver oxygen and nutrients to every part of the body, but also nourish
diseases such as cancer. Over the past decade, our understanding of the molecular …

New vessel formation (angiogenesis) is an essential physiological process for embryologic
development, normal growth, and tissue repair. Angiogenesis is tightly regulated at the …

Blood vessels form a closed circulatory system, whereas lymphatic vessels form a one-way
conduit for tissue fluid and leukocytes. In most vertebrates, the main function of lymphatic …

VEGFs (vascular endothelial growth factors) control vascular development during
embryogenesis and the function of blood vessels and lymphatic vessels in the adult. There …

The vascular endothelial growth factor (VEGF) family members, VEGF-A, placenta growth
factor (PlGF), and to a lesser extent VEGF-B, play an essential role in tumor-associated …

Solid tumors require blood vessels for growth and dissemination, and lymphatic vessels as
additional conduits for metastatic spread. The identification of growth factor receptor …

Aggressive and recurrent gynecological cancers are associated with worse prognosis and a
lack of effective therapeutic response. Ovarian cancer (OC) patients are often diagnosed in …