Targeted therapy for acute myeloid leukemia (AML) is an effective strategy, but currently
there are very limited therapeutic targets for AML treatment. Histone lysine specific …

Leukemia is a type of clonal disorders of hematopoietic stem and progenitor cells
characterized by bone marrow failure, differentiation arrest, and lineage skewing. Despite …

Chemotherapy, targeted therapy, and immunotherapy are effective against most tumors, but
drug resistance remains a barrier to successful treatment. Lysine-specific demethylase 1 …

All-trans retinoic acid (ATRA) plays a role in tissue development, neural function,
reproduction, vision, cell growth and differentiation, tumor immunity, and apoptosis. ATRA …

Histone methylation plays a key function in modulating gene expression, and preserving
genome integrity and epigenetic inheritance. However, aberrations of histone methylation …

The retinoic acid receptors (RARA, RARB, and RARG) are ligand-regulated nuclear
receptors that act as transcriptional switches. These master genes drew significant interest in …

Cancer cell heterogeneity is a major driver of therapy resistance. To characterize resistant
cells and their vulnerabilities, we studied the PLZF-RARA variant of acute promyelocytic …

A wealth of biochemical and cellular data, accumulated over several years by multiple
groups, has provided a great degree of insight into the molecular mechanisms of actions of …

Aberrant activity of the phosphatidylinositol‐3 kinase/protein kinase B/mammalian target of
rapamycin (PI3K/AKT/mTOR [PAM]) pathway, as well as suppressed retinoic acid signalling …

Abstract Caspase-1 (CASP1)-mediated classical pyroptosis plays a key role in cancer
development and management, however, the role of CASP1 and its regulation has not yet …