Multiscale computational modeling of vascular adaptation: a systems biology approach using agent-based models
The widespread incidence of cardiovascular diseases and associated mortality and
morbidity, along with the advent of powerful computational resources, have fostered an …
morbidity, along with the advent of powerful computational resources, have fostered an …
Mathematical modelling and simulation of atherosclerosis formation and progress: a review
NA Avgerinos, P Neofytou - Annals of Biomedical Engineering, 2019 - Springer
Cardiovascular disease (CVD) is a major threat to human health since it is the leading cause
of death in western countries. Atherosclerosis is a type of CVD related to hypertension …
of death in western countries. Atherosclerosis is a type of CVD related to hypertension …
Mathematical modelling of atheroma plaque formation and development in coronary arteries
Atherosclerosis is a vascular disease caused by inflammation of the arterial wall, which
results in the accumulation of low-density lipoprotein (LDL) cholesterol, monocytes …
results in the accumulation of low-density lipoprotein (LDL) cholesterol, monocytes …
Multilevel assessment of stent-induced inflammation in the adjacent vascular tissue
K Kapnisis, A Stylianou, D Kokkinidou… - ACS Biomaterials …, 2023 - ACS Publications
A recent US Food and Drug Administration report presented the currently available scientific
information related to biological response to metal implants. In this work, a multilevel …
information related to biological response to metal implants. In this work, a multilevel …
A predictive multiscale model of in-stent restenosis in femoral arteries: linking haemodynamics and gene expression with an agent-based model of cellular dynamics
In-stent restenosis (ISR) is a maladaptive inflammatory-driven response of femoral arteries
to percutaneous transluminal angioplasty and stent deployment, leading to lumen re …
to percutaneous transluminal angioplasty and stent deployment, leading to lumen re …
Arterial tissues and their inflammatory response to collagen damage: a continuum in silico model coupling nonlinear mechanics, molecular pathways, and cell …
M Gierig, P Wriggers, M Marino - Computers in Biology and Medicine, 2023 - Elsevier
Damage in soft biological tissues causes an inflammatory reaction that initiates a chain of
events to repair the tissue. This work presents a continuum model and its in silico …
events to repair the tissue. This work presents a continuum model and its in silico …
A fully coupled computational fluid dynamics–agent-based model of atherosclerotic plaque development: multiscale modeling framework and parameter sensitivity …
Abstract Background Peripheral Artery Disease (PAD) is an atherosclerotic disorder that
leads to impaired lumen patency through intimal hyperplasia and the build-up of plaques …
leads to impaired lumen patency through intimal hyperplasia and the build-up of plaques …
Simulation of atherosclerotic plaque growth using computational biomechanics and patient-specific data
Atherosclerosis is the one of the major causes of mortality worldwide, urging the need for
prevention strategies. In this work, a novel computational model is developed, which is used …
prevention strategies. In this work, a novel computational model is developed, which is used …
Computational modeling of in-stent restenosis: Pharmacokinetic and pharmacodynamic evaluation
Persistence of the pathology of in-stent restenosis even with the advent of drug-eluting
stents warrants the development of highly resolved in silico models. These computational …
stents warrants the development of highly resolved in silico models. These computational …
Mechanistic evaluation of long-term in-stent restenosis based on models of tissue damage and growth
Abstract Development and application of advanced mechanical models of soft tissues and
their growth represent one of the main directions in modern mechanics of solids. Such …
their growth represent one of the main directions in modern mechanics of solids. Such …