Heart failure with preserved ejection fraction (HFpEF) affects half of all patients with heart
failure worldwide, is increasing in prevalence, confers substantial morbidity and mortality …

Heart failure with preserved ejection fraction (HFpEF) represents one of the greatest
challenges facing cardiovascular medicine today. Despite being the most common form of …

Aging is associated with an increased risk of cardiovascular disease and death. Here we
show that oral supplementation of the natural polyamine spermidine extends the lifespan of …

Hypertension is the most common chronic disease in the world, yet the precise cause of
elevated blood pressure often cannot be determined. Animal models have been useful for …

Background: Although empagliflozin was shown to profoundly reduce cardiovascular events
in diabetic patients and blunt the decline in cardiac function in nondiabetic mice with …

Heart failure with preserved ejection fraction (HFpEF) is characterized by signs and
symptoms of heart failure in the presence of a normal left ventricular ejection fraction …

Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating
research to improve diagnostics, and to discover and test novel preventive and curative …

Observations in hemodialysis patients suggest a survival advantage associated with
activated vitamin D therapy. Left ventricular (LV) structural and functional abnormalities are …

Background—Heart failure with preserved ejection fraction is 1 consequence of
hypertension and is caused by impaired cardiac diastolic relaxation. Nitric oxide (NO) is a …

Heart failure with preserved ejection fraction (HFpEF) constitutes a clinical syndrome in
which the diagnostic criteria of heart failure are not accompanied by gross disturbances of …