During nervous system development, neurons extend axons to reach their targets and form
functional circuits. The faulty assembly or disintegration of such circuits results in disorders …

The spinal cord receives, relays and processes sensory information from the periphery and
integrates this information with descending inputs from supraspinal centres to elicit precise …

Transected axons fail to regrow in the mature central nervous system. Astrocytic scars are
widely regarded as causal in this failure. Here, using three genetically targeted loss-of …

The existence of evolutionarily conserved regions in the vertebrate brain is well established.
The rules and constraints underlying the evolution of neuron types, however, remain poorly …

Graded distributions of extracellular cues guide developing axons toward their targets. A
network of second messengers—Ca2+ and cyclic nucleotides—shapes cue-derived …

Precise patterning of axon guidance cue distribution is critical for nervous system
development. Using a murine forward genetic screen for novel determinants of axon …

Axonal connections between the left and right sides of the brain are crucial for bilateral
integration of lateralized sensory, motor, and associative functions. Throughout vertebrate …

The corpus callosum (CC) connects the cerebral hemispheres and is the major mammalian
commissural tract. It facilitates bilateral sensory integration and higher cognitive functions …

Background Human pluripotent stem cells (hPSCs) provide powerful models for studying
cellular differentiations and unlimited sources of cells for regenerative medicine. However, a …

The mammalian brain is the most complex organ in the body. It controls all aspects of our
bodily functions and interprets the world around us through our senses. It defines us as …