Ontologies have long been employed in the life sciences to formally represent and reason
over domain knowledge and they are employed in almost every major biological database …

Abstract Space biology research aims to understand fundamental spaceflight effects on
organisms, develop foundational knowledge to support deep space exploration and …

A deficient interferon (IFN) response to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection has been implicated as a determinant of severe coronavirus …

Motivation Understanding functions of proteins in specific human tissues is essential for
insights into disease diagnostics and therapeutics, yet prediction of tissue-specific cellular …

Although artificial neural networks are powerful classifiers, their internal structures are hard
to interpret. In the life sciences, extensive knowledge of cell biology provides an opportunity …

The topological landscape of molecular or functional interaction networks provides a rich
source of information for inferring functional patterns of genes or proteins. However, a …

Most diseases disrupt multiple proteins, and drugs treat such diseases by restoring the
functions of the disrupted proteins. How drugs restore these functions, however, is often …

Although gene discovery in neuropsychiatric disorders, including autism spectrum disorder,
intellectual disability, epilepsy, schizophrenia, and Tourette disorder, has accelerated …

We review the current applications of artificial intelligence (AI) in functional genomics. The
recent explosion of AI follows the remarkable achievements made possible by “deep …

Classically, phenotype is what is observed, and genotype is the genetic makeup. Statistical
studies aim to project phenotypic likelihoods of genotypic patterns. The traditional genotype …