Leukocytes play a vital role in immune responses, including defending against invasive
pathogens, reconstructing impaired tissue, and maintaining immune homeostasis. When the …

Immunogenic cell death (ICD) refers to an immunologically distinct process of regulated cell
death that activates, rather than suppresses, innate and adaptive immune responses. Such …

The treatment of cancer was revolutionized within the last two decades by utilizing the
mechanism of the immune system against malignant tissue in so-called cancer …

Dendritic cells (DCs) are a heterogeneous group of antigen-presenting innate immune cells
that regulate adaptive immunity, including against cancer. Therefore, understanding the …

The repertoire of naturally presented peptides within the MHC (major histocompatibility
complex) or HLA (human leukocyte antigens) system on the cellular surface of every …

The cellular stress and immunity cycle is a cornerstone of organismal homeostasis. Stress
activates intracellular and intercellular communications within a tissue or organ to initiate …

Immunotherapy is regarded as one of the most promising approaches for treating tumors,
with a multitude of immunotherapeutic thoughts currently under consideration for the lethal …

Tumour-associated macrophages (TAMs) are essential players in the tumour
microenvironment (TME) and modulate various pro-tumorigenic functions such as …

Efforts to treat cancer using chimeric antigen receptor (CAR)-T therapy have made
astonishing progress and clinical trials against hematopoietic malignancies have …

Current immunotherapies provide limited benefits against T cell-depleted tumors, calling for
therapeutic innovation. Using multi-omics integration of cancer patient data, we predict a …