Viral vectors have been used for a broad spectrum of gene therapy for both acute and
chronic diseases. In the context of cancer gene therapy, viral vectors expressing anti-tumor …

Single-stranded RNA viruses such as alphaviruses, flaviviruses, measles viruses and
rhabdoviruses are characterized by their capacity of highly efficient self-amplification of RNA …

Therapeutic cancer vaccines, designed to activate immune effectors against tumor antigens,
utilize a number of different platforms for antigen delivery. Among these are messenger …

Development of a cytomegalovirus (CMV) vaccine is a priority. We evaluated a two
component alphavirus replicon particle vaccine expressing CMV gB or a pp65/IE1 fusion …

Recombinant nucleic acids are considered as promising next-generation vaccines. These
vaccines express the native antigen upon delivery into tissue, thus mimicking live attenuated …

Alphaviruses, flaviviruses, measles viruses and rhabdoviruses are enveloped single-
stranded RNA viruses, which have been engineered for recombinant protein expression and …

Single-stranded RNA viruses of both positive and negative polarity have been used as
vectors for vaccine development. In this context, alphaviruses, flaviviruses, measles virus …

Chemotherapy is one of the most widely used approaches in combating advanced prostate
cancer, but its therapeutic efficacy is usually insufficient due to poor specificity and …

The development and success of RNA-based vaccines targeting SARS-CoV-2 has
awakened new interest in utilizing RNA vaccines against cancer, particularly in the …

Cancer vaccines, which activate the immune system against a target antigen, are attractive
for prostate cancer, where multiple upregulated protein targets are identified. However …