Leveraging protein dynamics to identify functional phosphorylation sites using deep learning models

F Zhu, S Yang, F Meng, Y Zheng, X Ku… - Journal of Chemical …, 2022 - ACS Publications
Accurate prediction of post-translational modifications (PTMs) is of great significance in
understanding cellular processes, by modulating protein structure and dynamics …

Research progress in protein posttranslational modification site prediction

W He, L Wei, Q Zou - Briefings in functional genomics, 2019 - academic.oup.com
Posttranslational modifications (PTMs) play an important role in regulating protein folding,
activity and function and are involved in almost all cellular processes. Identification of PTMs …

UbiSitePred: A novel method for improving the accuracy of ubiquitination sites prediction by using LASSO to select the optimal Chou's pseudo components

X Cui, Z Yu, B Yu, M Wang, B Tian, Q Ma - Chemometrics and Intelligent …, 2019 - Elsevier
Ubiquitination is an essential process in protein post-translational modification, which plays
a crucial role in cell life activities, such as proteasomal degradation, transcriptional …

DeepUbi: a deep learning framework for prediction of ubiquitination sites in proteins

H Fu, Y Yang, X Wang, H Wang, Y Xu - BMC bioinformatics, 2019 - Springer
Background Protein ubiquitination occurs when the ubiquitin protein binds to a target protein
residue of lysine (K), and it is an important regulator of many cellular functions, such as …

GPS-Uber: a hybrid-learning framework for prediction of general and E3-specific lysine ubiquitination sites

C Wang, X Tan, D Tang, Y Gou, C Han… - Briefings in …, 2022 - academic.oup.com
As an important post-translational modification, lysine ubiquitination participates in
numerous biological processes and is involved in human diseases, whereas the site …

Incorporating deep learning with word embedding to identify plant ubiquitylation sites

H Wang, Z Wang, Z Li, TY Lee - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Protein ubiquitylation is an important posttranslational modification (PTM), which is involved
in diverse biological processes and plays an essential role in the regulation of physiological …

[PDF][PDF] Journal of Mountain Area Research

R Sikander, A Ghulam, A Farman, DB Talpur… - 2022 - core.ac.uk
ABSTRACT A recent line of research has focused on Ubiquitination, a pervasive and
proteasome-mediated protein degradation that controls apoptosis and is crucial in the …

Large-scale prediction of protein ubiquitination sites using a multimodal deep architecture

F He, R Wang, J Li, L Bao, D Xu, X Zhao - BMC systems biology, 2018 - Springer
Background Ubiquitination, which is also called “lysine ubiquitination”, occurs when an
ubiquitin is attached to lysine (K) residues in targeting proteins. As one of the most important …

UbiComb: a hybrid deep learning model for predicting plant-specific protein ubiquitylation sites

A Siraj, DY Lim, H Tayara, KT Chong - Genes, 2021 - mdpi.com
Protein ubiquitylation is an essential post-translational modification process that performs a
critical role in a wide range of biological functions, even a degenerative role in certain …

Lysine 222 in PPAR γ1 functions as the key site of MuRF2-mediated ubiquitination modification

Y Fan, F Xu, R Wang, J He - Scientific Reports, 2023 - nature.com
Peroxisome proliferator-activated receptor gamma (PPAR γ) plays key roles in the
development, physiology, reproduction, and homeostasis of organisms. Its expression and …