The adult bone marrow has been generally considered to be composed of hematopoietic
tissue and the associated supporting stroma. Within the latter compartment, a subset of cells …

Regulated biophysical cues, such as nanotopography, have been shown to be integral for
tissue regeneration and embryogenesis in the stem cell niche. Tissue homeostasis involves …

Large-scale production of induced pluripotent stem cells (iPSCs) is essential for the
treatment of a variety of clinical indications. However, culturing enough iPSCs for clinical …

Developing biomaterials to promote stem cell proliferation and differentiation is a critical
requirement in tissue engineering and regeneration. Extracellular matrix (ECM) derived from …

To date, the development of phenotypically stable, functionally equivalent engineered
cartilage tissue constructs remains elusive. This study explored chondrogenic differentiation …

Natural extracellular matrix provides a number of distinct advantages for engineering
replacement orthopedic tissue due to its intrinsic functional properties. The goal of this study …

We have shown that human mesenchymal stem cells (hMSCs) have the potential to
differentiate into bone when seeded within three-dimensional (3-D) fibrin constructs …

Background Human periodontal ligament stem cells (hPDLSCs) are one of the most
promising types of seed cells in periodontal tissue regeneration. Suitable biomaterials are …

The extracellular matrix is a dynamic and active component of the mesenchymal stem cell
niche, which controls their differentiation and self-renewal. Traditional in vitro culture …

The extracellular matrix (ECM) of the embryonic heart guides assembly and maturation of
cardiac cell types and, thus, may serve as a useful template, or blueprint, for fabrication of …