Abstract The Netrin, Slit, Semaphorin, and Ephrin families of secreted proteins were
originally characterized in the nervous system as guidance cues for axons; however, recent …

Recent functional studies in mouse further illustrate the importance of the epithelial–
mesenchymal interaction between the ureteric bud epithelium and the metanephric …

Slit guidance ligand 2 (SLIT2) is a large, secreted protein that binds roundabout (ROBO)
receptors on multiple cell types, including neurons and kidney podocytes. SLIT2-ROBO …

Purpose.: The Roundabout (Robo) family of proteins is related to the transmembrane
receptors and plays a major role in neurogenesis. However, the role of the Robo proteins in …

Slit2 and Roundabout 1 (Robo1) provide a key ligand–receptor interaction for the navigation
of commissural neurons during the development of the central nervous system. Slit2 is a …

Purpose: Robo1, a member of the roundabout (Robo) family, serves as neuronal guidance
receptors and has been reported to mediate tumor angiogenesis. In this study, we …

另外3 个EGF 重复序列和1 个半恍氨酸富有区C 末端序列的蛋白质[2], 用不同的SLIT2
蛋白片段与ROBO 结合, 发现仅SLIT2rN 能结合Robo 受体, 由免疫沉淀实验证实SLIT …

To investigate the effect of the N-terminal Slit2 protein on neuronal survival and
development, recombinant human N-terminal Slit2 (N-Slit2) was assayed against isolated …

Recent analyses using spatial and temporal targeted genetic deletions of Hh signaling
components revealed lineage-specific requirements within the metanephric progenitor pool …

Hepatocellular carcinoma is the sixth most common cancer in the world, with an annual
incidence exceeding half a million. It is associated mainly with hepatitis B and C viral …