Engineering diselenide-IR780 homodimeric nanoassemblies with enhanced photodynamic and immunotherapeutic effects for triple-negative breast cancer treatment

Y Xue, K Chen, Y Chen, Y Liu, J Tang, X Zhang, J Liu - ACS nano, 2023 - ACS Publications
Photodynamic therapy (PDT) has emerged as an efficient approach for non-invasive cancer
treatment. However, organic small-molecule photosensitizers are often associated with …

Recent advances of lipid droplet-targeted AIE-active materials for imaging, diagnosis and therapy

S Yuan, E Zhao - Biosensors and Bioelectronics, 2024 - Elsevier
Lipid droplets (LDs) are cellular organelles specialized in the storage and regulated release
of lipids critical for energy metabolism. As investigation on LDs deepens, the complex …

A singular plasmonic-thermoelectric hollow nanostructure inducing apoptosis and cuproptosis for catalytic cancer therapy

L Yang, Z Zhao, B Tian, M Yang, Y Dong… - Nature …, 2024 - nature.com
Thermoelectric technology has recently emerged as a distinct therapeutic modality.
However, its therapeutic effectiveness is significantly limited by the restricted temperature …

Complexity made easy: Aggregation‐induced emission small molecules for cancer diagnosis and phototherapies

L Chen, SL Chen, Y Yuan, X Leng, X Xu, J Chen… - …, 2024 - Wiley Online Library
Phototheranostics has garnered sustained attention due to its significant potential for
revolutionizing conventional cancer treatment strategies. While being one of the most …

Glucose dysregulation promotes oncogenesis in human bladder cancer by regulating autophagy and YAP1/TAZ expression

S Li, B Ruan, Z Wang, J Xia, Q Lin, R Xu… - Journal of Cellular …, 2023 - Wiley Online Library
Glucose dysregulation is strongly correlated with cancer development, and cancer is
prevalent in patients with Type 2 diabetes (T2D). We aimed to elucidate the mechanism …

AIE-active lysosome-targeted fluorescent organic nanoparticles for leucine aminopeptidase-activatable fluorescent imaging and precision photodynamic therapy …

W Zhou, Y Liu, Q Ma, G Feng, J Zhang, G Liu… - Dyes and …, 2024 - Elsevier
Leucine aminopeptidase (LAP) is a vital proteolytic enzyme, and its overexpression is often
associated with many physiological diseases. Stimuli-activatable photosensitizer (PS) has …

Mitochondria–Nucleus Migration Probe for Ultrasensitive Monitoring of mtDNA Damage in Living Cells

ZQ Yu, W Pan, X Yang, M Tian, J Zhang, H Liu… - Analytical …, 2024 - ACS Publications
Mitochondrial DNA (mtDNA) damage is a prevalent phenomenon that has been proven to
be implicated in a wide spectrum of diseases. However, the progressive attenuation of probe …

Cancer-cell-specific Self-Reporting Photosensitizer for Precise Identification and Ablation of Cancer Cells

R Zhang, C Zhang, Q Lu, C Liang, M Tian, Z Li… - Analytical …, 2024 - ACS Publications
Cancer-cell-specific fluorescent photosensitizers (PSs) are highly desired molecular tools for
cancer ablation with minimal damage to normal cells. However, such PSs that can achieve …

Development of Novel β-Carboline/Furylmalononitrile Hybrids as Type I/II Photosensitizers with Chemo-Photodynamic Therapy and Minimal Toxicity

X Xie, T Sun, H Pan, D Ji, Z Xu, G Gao… - Molecular …, 2024 - ACS Publications
Chemo-photodynamic therapy is a treatment method that combines chemotherapy and
photodynamic therapy and has demonstrated significant potential in cancer treatment …

A dual-functional photosensitizer for mitochondria-targeting photodynamic therapy and synchronous polarity monitoring

L Yang, S Gan, J Zhang, Y Jiang, Q Chen… - Journal of Materials …, 2024 - pubs.rsc.org
Mitochondria-targeting photodynamic therapy (PDT) has been validated as an effective
strategy for inducing cell death through the disruption of mitochondrial function. The …