The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation to
understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family …

Interleukein-6 (IL-6), is produced locally from infectious or injured lesions and is delivered to
the whole body via the blood stream, promptly activating the host defense system to perform …

Embryo implantation involves the intimate interaction between an implantation-competent
blastocyst and a receptive uterus, which occurs in a limited time period known as the …

The ob gene product, leptin, is an important circulating signal for the regulation of body
weight. To identify high affinity leptin-binding sites, we generated a series of leptin-alkaline …

The family of cytokines signalling through the common receptor subunit gp130 comprises
interleukin (IL)-6, IL-11, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor …

OB-R is a high affinity receptor for leptin, an important circulating signal for the regulation of
body weight. We identified an alternatively spliced transcript that encodes a form of mouse …

The propagation of embryonic stem (ES) cells in an undifferentiated pluripotent state is
dependent on leukemia inhibitory factor (LIF) or related cytokines. These factors act through …

Successful implantation is the result of reciprocal interactions between the implantation-
competent blastocyst and receptive uterus. Although various cellular aspects and molecular …

▪ Abstract Receptors for most interleukins and cytokines that regulate immune and
hematopoietic systems belong to the class I cytokine receptor family. These molecules form …

Acute-phase response factor (APRF) is a transcription factor that blnds to the Interfeukln-6
(IL-@-responsive elements identlfled In the promoters of various acutephase protein genes …