Ergosterol is an essential component of fungal cell membranes that determines the fluidity,
permeability and activity of membrane-associated proteins. Ergosterol biosynthesis is a …

Macroautophagy is an evolutionarily conserved dynamic pathway that functions primarily in
a degradative manner. A basal level of macroautophagy occurs constitutively, but this …

The genome-wide architecture of chromatin-associated proteins that maintains chromosome
integrity and gene regulation is not well defined. Here we use chromatin …

Transcription factors (TFs) that bind common DNA motifs in vitro occupy distinct sets of
promoters in vivo, raising the question of how binding specificity is achieved. TFs are …

Reconstructing gene regulatory networks from high-throughput data is a long-standing
challenge. Through the Dialogue on Reverse Engineering Assessment and Methods …

Histone acetylation is a ubiquitous hallmark of transcription, but whether the link between
histone acetylation and transcription is causal or consequential has not been addressed …

The transport of pyruvate, the end product of glycolysis, into mitochondria is an essential
process that provides the organelle with a major oxidative fuel. Although the existence of a …

The MEME Suite web server provides a unified portal for online discovery and analysis of
sequence motifs representing features such as DNA binding sites and protein interaction …

A critical step in the analysis of large genome-wide gene expression datasets is the use of
module detection methods to group genes into co-expression modules. Because of …

Chromatin immunoprecipitation (ChIP-chip and ChIP-seq) assays identify where proteins
bind throughout a genome. However, DNA contamination and DNA fragmentation …