Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to
growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of …

Mechanical interactions between tumors and the extracellular matrix (ECM) of the
surrounding tissues have profound effects on a wide variety of cellular functions. An …

The sialyltransferase ST6GAL1 that adds α2–6 linked sialic acids to N-glycans of cell
surface and secreted glycoproteins is prominently associated with many human cancers …

Transitional B cells (TrB cells) represent a crucial link between immature B cells in the bone
marrow and mature peripheral B cells. Although TrB cells represent one of the regulatory B …

All cells are decorated with complex carbohydrate structures called glycans that serve as
ligands for glycan-binding proteins (GBPs) to mediate a wide range of biological processes …

Despite over a century of research, Mycobacterium tuberculosis (Mtb), the causative agent of
tuberculosis (TB), continues to kill 1.5 million people annually. Though less than 10% of …

Recent reports have documented that extracellular sialyltransferases can remodel both cell-
surface and secreted glycans by a process other than the canonical cell-autonomous …

Background Multiple myeloma is characterized by clonal proliferation of malignant plasma
cells in the bone marrow that produce monoclonal immunoglobulins. N-glycosylation …

Glycosylation of proteins and lipids is of fundamental importance in multicellular eukaryotes.
The vast diversity of glycan structures observed is generated in the Golgi apparatus by the …

Humoral immunity is an effective but metabolically expensive defense mechanism. It is
unclear whether systemic cues exist to communicate the dynamic need for antigen …