The N‐end rule relates the regulation of the in vivo half‐life of a protein to the identity of its N‐
terminal residue. Degradation signals (degrons) that are targeted by the N‐end rule pathway …

Factor XIII (FXIII) is unique among clotting factors for a number of reasons: 1) it is a
protransglutaminase, which becomes activated in the last stage of coagulation; 2) it works …

Transglutaminases (Tgases) are a widely distributed group of enzymes that catalyse the
post-translational modification of proteins by the formation of isopeptide bonds. This occurs …

The N-end rule pathway is a proteolytic system in which N-terminal residues of short-lived
proteins are recognized by recognition components (N-recognins) as essential components …

The human transglutaminase (TG) family consists of a structural protein, protein 4.2, that
lacks catalytic activity, and eight zymogens/enzymes, designated factor XIII-A (FXIII-A) and …

The clinical importance of fibrin stabilizing factor ago, when Barkan and Gaspar [1]
demonbecame apparent when in 1960 Duckert and colstrated that fibrin clots that were …

The crystal structure of a microbial transglutaminase from Streptoverticillium mobaraense
has been determined at 2.4 Å resolution. The protein folds into a plate-like shape, and has …

Transglutaminases form a family of proteins that have evolved for specialized functions such
as protein crosslinking in haemostasis, semen coagulation, or keratinocyte cornified …

ZED1227 is a small molecule tissue transglutaminase (TG2) inhibitor. The compound
selectively binds to the active state of TG2, forming a stable covalent bond with the cysteine …

We recently mapped the disease locus for severe autosomal recessive lamellar ichthyosis
(LI) to chromosome 14q11 and showed complete linkage with TGM1, the gene encoding …