Repetitive elements in the human genome, once considered 'junk DNA', are now known to
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …

Genome instability, defined as higher than normal rates of mutation, is a double-edged
sword. As a source of genetic diversity and natural selection, mutations are beneficial for …

Conflicts between transcription and replication are a potent source of DNA damage. Co-
transcriptional R-loops could aggravate such conflicts by creating an additional barrier to …

Plasmid acquisition is an important mechanism of rapid adaptation and niche expansion in
prokaryotes. Positive selection for plasmid-coded functions is a major driver of plasmid …

Genomic alterations driving tumorigenesis result from the interaction of environmental
exposures and endogenous cellular processes. With a diversity of risk factors, liver cancer is …

The complex machineries involved in replication and transcription translocate along the
same DNA template, often in opposing directions and at different rates. These processes …

Aberrant replication causes cells lacking BRCA2 to enter mitosis with under-replicated DNA,
which activates a repair mechanism known as mitotic DNA synthesis (MiDAS). Here, we …

DNA damage is the cause of numerous human pathologies including cancer, premature
aging, and chronic inflammatory conditions. The DNA damage response (DDR), in turn …

Complete and accurate DNA replication is essential to genome stability maintenance during
cellular division. However, cells are routinely challenged by endogenous as well as …

Complex genomic rearrangements (CGRs) are common in cancer and are known to form via
two aberrant cellular structures—micronuclei and chromatin bridges. However, which of …