Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives

JS Bhatti, A Sehrawat, J Mishra, IS Sidhu… - Free Radical Biology …, 2022 - Elsevier
Abstract Type 2 diabetes (T2DM) is a persistent metabolic disorder rising rapidly worldwide.
It is characterized by pancreatic insulin resistance and β-cell dysfunction. Hyperglycemia …

Cellular and molecular mechanisms of curcumin in prevention and treatment of disease

SS Patel, A Acharya, RS Ray, R Agrawal… - Critical reviews in …, 2020 - Taylor & Francis
Curcumin is a naturally occurring polyphenolic compound present in rhizome of Curcuma
longa belonging to the family zingiberaceae. Growing experimental evidence revealed that …

Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century

WH Lee, CY Loo, M Bebawy, F Luk… - Current …, 2013 - ingentaconnect.com
Curcumin (diferuloylmethane), a polyphenol extracted from the plant Curcuma longa, is
widely used in Southeast Asia, China and India in food preparation and for medicinal …

Small molecule modulators of K eap1‐N rf2‐ARE pathway as potential preventive and therapeutic agents

S Magesh, Y Chen, L Hu - Medicinal research reviews, 2012 - Wiley Online Library
K elch‐like ECH‐associated protein 1 (K eap1)‐nuclear factor erythroid 2‐related factor 2 (N
rf2)‐antioxidant response elements (ARE) pathway represents one of the most important …

Biological and therapeutic activities, and anticancer properties of curcumin

D Perrone, F Ardito… - Experimental and …, 2015 - spandidos-publications.com
Curcumin (diferuloylmethane) is a polyphenol derived from the Curcuma longa plant.
Curcumin has been used extensively in Ayurvedic medicine, as it is nontoxic and exhibits a …

Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population

KHM Cox, A Pipingas… - Journal of …, 2015 - journals.sagepub.com
Curcumin possesses many properties which may prevent or ameliorate pathological
processes underlying age-related cognitive decline, dementia or mood disorders. These …

Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders

V Calabrese, C Cornelius… - Antioxidants & redox …, 2010 - liebertpub.com
Despite the capacity of chaperones and other homeostatic components to restore folding
equilibrium, cells appear poorly adapted for chronic oxidative stress that increases in cancer …

Curcumin: from ancient medicine to current clinical trials

H Hatcher, R Planalp, J Cho, FM Torti… - Cellular and molecular life …, 2008 - Springer
Curcumin is the active ingredient in the traditional herbal remedy and dietary spice turmeric
(Curcuma longa). Curcumin has a surprisingly wide range of beneficial properties, including …

Curcumin: the Indian solid gold

BB Aggarwal, C Sundaram, N Malani… - The molecular targets and …, 2007 - Springer
Turmeric, derived from the plant Curcuma longa, is a gold-colored spice commonly used in
the Indian subcontinent, not only for health care but also for the preservation of food and as …

Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity

V Calabrese, C Mancuso, M Calvani… - Nature reviews …, 2007 - nature.com
At the end of the 1980s, it was clearly demonstrated that cells produce nitric oxide and that
this gaseous molecule is involved in the regulation of the cardiovascular, immune and …