Mechanical stimulation: a crucial element of organ-on-chip models
CL Thompson, S Fu, HK Heywood… - … in bioengineering and …, 2020 - frontiersin.org
Organ-on-chip (OOC) systems recapitulate key biological processes and responses in vitro
exhibited by cells, tissues, and organs in vivo. Accordingly, these models of both health and …
exhibited by cells, tissues, and organs in vivo. Accordingly, these models of both health and …
Advances in microphysiological blood-brain barrier (BBB) models towards drug delivery
Highlights•Various approaches exist to recreate 2D and 3D structures of the
BBB.•Quantitative barrier functions in some BBB-chips are comparable to in vivo …
BBB.•Quantitative barrier functions in some BBB-chips are comparable to in vivo …
Cellular interactions of liposomes and PISA nanoparticles during human blood flow in a microvascular network
A key concept in nanomedicine is encapsulating therapeutic or diagnostic agents inside
nanoparticles to prolong blood circulation time and to enhance interactions with targeted …
nanoparticles to prolong blood circulation time and to enhance interactions with targeted …
Opportunities and challenges in delivering biologics for Alzheimer's disease by low-intensity ultrasound
Low-intensity ultrasound combined with intravenously injected microbubbles (US+ MB) is a
novel treatment modality for brain disorders, including Alzheimer's disease (AD), safely and …
novel treatment modality for brain disorders, including Alzheimer's disease (AD), safely and …
Unlocking neural function with 3D in vitro models: A technical review of self-assembled, guided, and bioprinted brain organoids and their applications in the study of …
Understanding the complexities of the human brain and its associated disorders poses a
significant challenge in neuroscience. Traditional research methods have limitations in …
significant challenge in neuroscience. Traditional research methods have limitations in …
A 3D‐bioprinted vascularized glioblastoma‐on‐a‐chip for studying the impact of simulated microgravity as a novel pre‐clinical approach in brain tumor therapy
Glioblastoma multiforme (GBM) is one of the most aggressive malignant brain tumors and
urgently requires the development of new therapeutic strategies. In this study, an innovative …
urgently requires the development of new therapeutic strategies. In this study, an innovative …
Tumor-on-a-chip platforms to study cancer–immune system crosstalk in the era of immunotherapy
S Parlato, G Grisanti, G Sinibaldi, G Peruzzi… - Lab on a Chip, 2021 - pubs.rsc.org
Immunotherapy is a powerful therapeutic approach able to re-educate the immune system to
fight cancer. A key player in this process is the tumor microenvironment (TME), which is a …
fight cancer. A key player in this process is the tumor microenvironment (TME), which is a …
[HTML][HTML] High-throughput microfluidics for evaluating microbubble enhanced delivery of cancer therapeutics in spheroid cultures
Drug penetration into solid tumours remains a major challenge in the effective treatment of
cancer. Microbubble (MB) mediated sonoporation offers a potential solution to this by …
cancer. Microbubble (MB) mediated sonoporation offers a potential solution to this by …
Cell membrane mechanics and mechanosensory transduction
The rapid progress in mechanobiology has brought together many scientific and
engineering disciplines to work hand in hand toward better understanding of the role that …
engineering disciplines to work hand in hand toward better understanding of the role that …
Fundamentals, biomedical applications and future potential of micro-scale cavitation-a review
Thanks to the developments in the area of microfluidics, the cavitation-on-a-chip concept
enabled researchers to control and closely monitor the cavitation phenomenon in micro …
enabled researchers to control and closely monitor the cavitation phenomenon in micro …