Biofabricated tissues have found numerous applications in tissue engineering and
regenerative medicine in addition to the promotion of disease modeling and drug …

Bone is a highly vascularized tissue, and its development, maturation, remodeling, and
regeneration are dependent on a tight regulation of blood vessel supply. This condition also …

3D cell culture methods confer a high degree of clinical and biological relevance to in vitro
models. This is specifically the case with the spheroid culture, where a small aggregate of …

Abstract Design and synthesis of efficient drug delivery systems are of vital importance for
medicine and healthcare. Nanocarrier-based drug delivery systems, in particular …

Introduction: Developing in vitro models for studying cell biology and cell physiology is of
great importance to the fields of biotechnology, cancer research, drug discovery, toxicity …

Embryogenic developmental processes involve a tightly controlled regulation between
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …

Bone vasculature plays a vital role in bone development, remodeling and homeostasis. New
blood vessel formation is crucial during both primary bone development as well as fracture …

Creating vascular networks in tissues is crucial for tissue engineering. Although recent
studies have demonstrated the formation of vessel-like structures in a tissue model, long …

Tissue engineering is currently limited by the inability to adequately vascularize tissues in
vitro or in vivo. Issues of nutrient perfusion and mass transport limitations, especially oxygen …

Tissue engineering has been an active field of research for several decades now. However,
the amount of clinical applications in the field of tissue engineering is still limited. One of the …