Mechanism of thrombocytopenia in COVID-19 patients

P Xu, Q Zhou, J Xu - Annals of hematology, 2020 - Springer
Since December 2019, a novel coronavirus has spread throughout China and across the
world, causing a continuous increase in confirmed cases within a short period of time. Some …

Mechanisms involved in the development of thrombocytopenia in patients with COVID-19

Y Zhang, X Zeng, Y Jiao, Z Li, Q Liu, J Ye, M Yang - Thrombosis research, 2020 - Elsevier
Abstract Corona Virus Disease 2019 (COVID-19) is caused by the novel coronavirus SARS-
CoV-2. Emerging genetic and clinical evidence suggests similarities between COVID-19 …

[HTML][HTML] Hematological abnormalities in COVID-19: a narrative review

A Rahman, R Niloofa, U Jayarajah… - The American journal …, 2021 - ncbi.nlm.nih.gov
ABSTRACT COVID-19 is caused by SARS-CoV-2. Although pulmonary manifestations have
been identified as the major symptoms, several hematological abnormalities have also been …

Platelets and the immune continuum

JW Semple, JE Italiano, J Freedman - Nature Reviews Immunology, 2011 - nature.com
Platelets are anucleate cells that are crucial mediators of haemostasis. Most immunologists
probably don't think about platelets every day, and may even consider these cells to …

Emerging concepts in immune thrombocytopenia

M Swinkels, M Rijkers, J Voorberg… - Frontiers in …, 2018 - frontiersin.org
Immune thrombocytopenia (ITP) is an autoimmune disease defined by low platelet counts
which presents with an increased bleeding risk. Several genetic risk factors (eg …

The ITP syndrome: pathogenic and clinical diversity

DB Cines, JB Bussel, HA Liebman… - Blood, The Journal of …, 2009 - ashpublications.org
Immune thrombocytopenia (ITP) is mediated by platelet autoantibodies that accelerate
platelet destruction and inhibit their production. Most cases are considered idiopathic …

Immune thrombocytopenia

G Kistanguri, KR McCrae - Hematology/oncology clinics of …, 2013 - pmc.ncbi.nlm.nih.gov
Immune thrombocytopenia (ITP) is a common hematologic disorder characterized by
isolated thrombocytopenia. ITP presents as a primary form characterized by isolated …

Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro

M Chang, PA Nakagawa, SA Williams, MR Schwartz… - Blood, 2003 - ashpublications.org
To determine if megakaryocytes are targeted by immune thrombocytopenic purpura (ITP)
autoantibodies, as are platelets, we have studied the effects of ITP plasma on in vitro …

A meta-analysis of potential biomarkers associated with severity of coronavirus disease 2019 (COVID-19)

C Danwang, FT Endomba, JR Nkeck, DLA Wouna… - Biomarker …, 2020 - Springer
Background Prognostic factors for the Coronavirus disease 2019 (COVID1–9) are not well
established. This study aimed to summarize the available data on the association between …

Platelet-and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV

T Rozmyslowicz, M Majka, J Kijowski, SL Murphy… - Aids, 2003 - journals.lww.com
Objective: Under some circumstances the HIV virus may infect cells that do not express
receptors essential to HIV-entry. We hypothesized that platelet-and megakaryocyte-derived …