K Paigen, PM Petkov - Trends in Genetics, 2018 - cell.com
PRDM9 is a zinc finger protein that binds DNA at specific locations in the genome where it trimethylates histone H3 at lysines 4 and 36 at surrounding nucleosomes. During meiosis in …
To investigate the consequences of hybridization between species, we studied three replicate hybrid populations that formed naturally between two swordtail fish species …
The DNA-binding protein PRDM9 has a critical role in specifying meiotic recombination hotspots in mice and apes, but it appears to be absent from other vertebrate species …
P Moorjani, CEG Amorim, PF Arndt… - Proceedings of the …, 2016 - National Acad Sciences
Events in primate evolution are often dated by assuming a constant rate of substitution per unit time, but the validity of this assumption remains unclear. Among mammals, it is well …
In some mammals, notably humans, recombination occurs almost exclusively where the protein PRDM9 binds, whereas in vertebrates lacking an intact PRDM9, such as birds and …
Genetic admixture is central to primate evolution. We combined 50 years of field observations of immigration and group demography with genomic data from~ 9 generations …
G Li, HV Figueiró, E Eizirik… - Molecular biology and …, 2019 - academic.oup.com
Current phylogenomic approaches implicitly assume that the predominant phylogenetic signal within a genome reflects the true evolutionary history of organisms, without assessing …
Meiosis is a key event of sexual life cycles in eukaryotes. Its mechanistic details have been uncovered in several model organisms, and most of its essential features have received …
C Grey, F Baudat, B de Massy - PLoS genetics, 2018 - journals.plos.org
During meiosis, maternal and paternal chromosomes undergo exchanges by homologous recombination. This is essential for fertility and contributes to genome evolution. In many …