Understanding the genetic basis of variation in meiotic recombination: past, present, and future

SE Johnston - Molecular Biology and Evolution, 2024 - academic.oup.com
Meiotic recombination is a fundamental feature of sexually reproducing species. It is often
required for proper chromosome segregation and plays important role in adaptation and the …

PRDM9 and its role in genetic recombination

K Paigen, PM Petkov - Trends in Genetics, 2018 - cell.com
PRDM9 is a zinc finger protein that binds DNA at specific locations in the genome where it
trimethylates histone H3 at lysines 4 and 36 at surrounding nucleosomes. During meiosis in …

Natural selection interacts with recombination to shape the evolution of hybrid genomes

M Schumer, C Xu, DL Powell, A Durvasula, L Skov… - Science, 2018 - science.org
To investigate the consequences of hybridization between species, we studied three
replicate hybrid populations that formed naturally between two swordtail fish species …

Stable recombination hotspots in birds

S Singhal, EM Leffler, K Sannareddy, I Turner, O Venn… - Science, 2015 - science.org
The DNA-binding protein PRDM9 has a critical role in specifying meiotic recombination
hotspots in mice and apes, but it appears to be absent from other vertebrate species …

Variation in the molecular clock of primates

P Moorjani, CEG Amorim, PF Arndt… - Proceedings of the …, 2016 - National Acad Sciences
Events in primate evolution are often dated by assuming a constant rate of substitution per
unit time, but the validity of this assumption remains unclear. Among mammals, it is well …

Patterns of recombination in snakes reveal a tug-of-war between PRDM9 and promoter-like features

C Hoge, M de Manuel, M Mahgoub, N Okami, Z Fuller… - Science, 2024 - science.org
In some mammals, notably humans, recombination occurs almost exclusively where the
protein PRDM9 binds, whereas in vertebrates lacking an intact PRDM9, such as birds and …

Selection against admixture and gene regulatory divergence in a long-term primate field study

TP Vilgalys, AS Fogel, JA Anderson, RS Mututua… - Science, 2022 - science.org
Genetic admixture is central to primate evolution. We combined 50 years of field
observations of immigration and group demography with genomic data from~ 9 generations …

Recombination-aware phylogenomics reveals the structured genomic landscape of hybridizing cat species

G Li, HV Figueiró, E Eizirik… - Molecular biology and …, 2019 - academic.oup.com
Current phylogenomic approaches implicitly assume that the predominant phylogenetic
signal within a genome reflects the true evolutionary history of organisms, without assessing …

Evolutionary mysteries in meiosis

T Lenormand, J Engelstädter… - … of the Royal …, 2016 - royalsocietypublishing.org
Meiosis is a key event of sexual life cycles in eukaryotes. Its mechanistic details have been
uncovered in several model organisms, and most of its essential features have received …

PRDM9, a driver of the genetic map

C Grey, F Baudat, B de Massy - PLoS genetics, 2018 - journals.plos.org
During meiosis, maternal and paternal chromosomes undergo exchanges by homologous
recombination. This is essential for fertility and contributes to genome evolution. In many …